Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample

Soh, Chai Rick; Pietrobon, Ricardo; Freiberger, JJ; Chew, Sophia Tsong Huey; Rajgor, Dimple; Gandhi, Mihir; Shah, Jatin; Moon, Richard E.

doi:10.1007/s00134-012-2558-4

Cited by 64 publications

(41 citation statements)

References 35 publications

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“…Hyperbaric oxygen therapy seems to be a logical treatment of refractory ischemic lesion [4]. In the present case, such treatment apparently accelerated regression of the pelvic pain and vaginal lesions.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 88%

Hyperbaric oxygen therapy in a case of vaginal and uterine necrosis after embolization for postpartum hemorrhage

Gautier

Midulla

Lucot

et al. 2015

Intl J Gynecology & Obste

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Section: Contents Lists Available At Sciencedirectmentioning

confidence: 88%

Hyperbaric oxygen therapy in a case of vaginal and uterine necrosis after embolization for postpartum hemorrhage

Gautier

Midulla

Lucot

et al. 2015

Intl J Gynecology & Obste

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“…Antibiotics such as penicillin, piperacillin/tazobactam, or carbapenems are used with clindamycin (this is bacteriostatic and inhibits Streptococcus superantigen [16]). Some experimental adjunct therapies (hyperbaric oxygen or intravenous immunoglobulins) have been reported in selected groups but the results are contradictory and controversial [17]. …”

Section: Discussionmentioning

confidence: 99%

Necrotizing Myositis in a Neutropenic Patient: The Use of Ultrasound in the Diagnosis of Atypical Presentations

Torrejón

Celi

Cancho

et al. 2014

Case Reports in Emergency Medicine

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We report a case of fatal necrotizing soft tissue infection (NSTI) due to Clostridium perfringens (CP) in a neutropenic patient with diabetes mellitus. As in many cases, by the time a diagnosis was made, the condition had rapidly progressed to its late stages, resulting in a fatal outcome. The emergency physician should be aware of NSTI as a complication when patients present with pain out of proportion to physical findings and/or signs of soft tissue compromise. Negative prognostic factors for survival are diabetes mellitus, immunosuppression, age, and toxic shock syndrome. A bedside ultrasound scan allows for rapid evaluation in time-sensitive critically ill patients and can promote prompt treatment without the need to delay for further imaging studies.

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“…10, [12][13][14] The therapeutic protocol ministered at our center consists of HBO sessions at 2.8 ATM for 90 minutes ( Fig. 1 -top) twice daily until the infection is controlled (until 2011 the protocol was 90 minutes of HBO at 2.5 ATM twice daily) followed by HBO daily sessions at 2.5 ATM for 75 minutes until the condition is fully resolved (Fig.…”

Section: 11mentioning

confidence: 99%

Hyperbaric Oxygen Therapy for the Treatment of Fournier’s Gangrene: A Review of 34 Cases

Rosa¹,

Guerreiro²

2015

Acta Med Port

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Material and Methods:The data presented in this study encompass a period of 25 years of clinical records of patients with Fournier's gangrene that had been treated at our center with hyperbaric oxygen therapy.Results: A total of 34 patients were treated. The vast majority of patients were males (94.1%) with a mean age of 53.7 years. Urinary tract was the most frequent source of infection and diabetes was most common comorbidity seen in patients. Mortality rate was 20.8%. Discussion: The most common observed comorbidity was diabetes, suggesting diabetes as one predisposing factor. The majority of deceased patients had diabetes, although no significant correlation between diabetes and death was found. The area of residence of patients may affect patients' referral to these facilities. Conclusions: Although Fournier's gangrene is a rare condition, it is nevertheless a fatal illness, namely in patients with comorbidities like diabetes. Hyperbaric oxygen therapy is recommended as an adjuvant to conventional therapy and should be considered whenever available. To further assess the role of hyperbaric oxygen therapy, in the treatment of this condition, additional studies should be carried out.

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Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample

Abstract: This retrospective analysis of HBO(2) therapy in NSTI showed that despite the higher hospitalisation cost and longer length of stay, the statistically significant reduction in mortality supports the use of HBO(2) therapy in NSTI.

Cited by 64 publications

References 35 publications

Hyperbaric oxygen therapy in a case of vaginal and uterine necrosis after embolization for postpartum hemorrhage

Hyperbaric oxygen therapy in a case of vaginal and uterine necrosis after embolization for postpartum hemorrhage

Necrotizing Myositis in a Neutropenic Patient: The Use of Ultrasound in the Diagnosis of Atypical Presentations

Hyperbaric Oxygen Therapy for the Treatment of Fournier’s Gangrene: A Review of 34 Cases

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