Hyperbaric Oxygen Therapy in Systemic Inflammatory Response Syndrome

Abstract

(1) Background: Systemic inflammatory response syndrome (SIRS) can occur due to a large number of traumatic or non-traumatic diseases. Hyperbaric oxygen therapy (HBOT) may be used as a main or adjuvant treatment for inflammation, leading to the main aim of this study, which was to verify the applicability of HBOT as a safe and tolerable tool in SIRS-positive dogs. (2) Methods: This prospective cohort study included 49 dogs who showed two or more parameters of SIRS, divided into the Traumatic Study Group (n = 32) and the Non-Traumatic Study Group (n = 17). All dogs were submitted to HBOT for 60–90 min sessions, with 2.4–2.8 ATA. (3) Results: This study revealed that 73.5% (36/49) of dogs showed improvement, and the minimum number of HBOT sessions was two, with a mean of 12.73. The number of days between diagnosis and the beginning of HBOT showed statistical significance (p = 0.031) relative to the clinical outcome. No dogs showed any major side effects. (4) Conclusions: We concluded that HBOT may be safe and tolerable for SIRS-positive dogs, and that it should be applied as early as possible.

A oxigenoterapia hiperbárica veterinária integrada ao tratamento da necrose tecidual e osteomielite em cão: relato de caso

“…A despeito da oxigenoterapia hiperbárica mostrar-se benéfica para o tratamento de curto prazo de feridas crônicas e hipóxicas em humanos, não existiam dados sobre a sua utilização na Medicina Veterinária (FOSSUM, 2019). Contudo, em respeitosa, porém franca divergência a tal afirmação, há na atualidade um crescente e considerável volume de trabalhos sobre o tema: Elan (2019), Gautier et al (2020), Gouveia et al (2021Gouveia et al ( , 2022, Hochman e Shmalberg (2017), Levitan et al (2021), Mazzi (2018Mazzi ( , 2022, Mazzi e Dias (2021), Schmidt (2021).…”

The effects of hyperbaric oxygen therapy on snake‐bite‐associated wounds in dogs

“…11,13 Secondary effects may include enhanced antimicrobial (eg, direct and indirect antibacterial and antifungal), immunomodulatory (eg, enhances leukocyte function, reduces inflammation), and angiogenic effects (eg, stimulates neovascularization, increases growth factor synthesis, enhances vascular endothelial growth factor-induced endothelial cell growth), pain modulation, and other benefits. 11,13,15,16 In people, the accepted indications for HBOT from the Undersea and Hyperbaric Medical Soci-ety include decompression sickness, gas embolism, carbon monoxide poisoning, anaerobic or mixed bacterial infections, necrotizing soft tissue infections, open fractures or crush injury, compartment syndrome and other acute traumatic ischemias, delayed wound healing, compromised skin grafts, radionecrosis, sudden deafness, select brain injuries, severe blood loss anemia, acute thermal burns, and refractory osteomyelitis. 12,[17][18][19] Some research has described the use of HBOT for the treatment of venomous snake bites in rodent and rat models, as well as in people.…”