Hyperbaric Oxygen Therapy in the Management of Radiation-Induced Injury in the Head and Neck Region: A Review of the Literature

Spiegelberg, Linda; Djasim, Urville M.; Neck, Han W. van; Wolvius, Eppo B.; Wal, K G van der

doi:10.1016/j.joms.2010.02.040

Cited by 52 publications

(50 citation statements)

References 63 publications

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“…In the case of the prevention or treatment of xerostomia, some clinical trials report positive effects of HBOT (6)(7)(8), mostly measured by quality of life questionnaires. Experimental evidence on the beneficial effects of HBOT on irradiated salivary glands is however scarce (9). In a previous study we showed an increased blood vessel density in irradiated mouse salivary glands in response to HBOT (10).…”

Section: Introductionmentioning

confidence: 91%

Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

Spiegelberg

Swagemakers

IJcken

et al. 2014

Mol Med

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A side effect of radiation therapy in the head and neck region is injury to surrounding healthy tissues such as irreversible impaired function of the salivary glands. Hyperbaric oxygen therapy (HBOT) is clinically used to treat radiation-induced damage but its mechanism of action is largely unknown. In this study, we investigated the molecular pathways that are affected by HBOT in mouse salivary glands two weeks after radiation therapy by microarray analysis. Interestingly, HBOT led to significant attenuation of the radiation-induced expression of a set of genes and upstream regulators that are involved in processes such as fibrosis and tissue regeneration. Our data suggest that the TGFβ-pathway, which is involved in radiation-induced fibrosis and chronic loss of function after radiation therapy, is affected by HBOT. On the longer term, HBOT reduced the expression of the fibrosis-associated factor α-smooth muscle actin in irradiated salivary glands. This study highlights the potential of HBOT to inhibit the TGFβ-pathway in irradiated salivary glands and to restrain consequential radiation induced tissue injury.

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Section: Introductionmentioning

confidence: 91%

Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

Spiegelberg

Swagemakers

IJcken

et al. 2014

Mol Med

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“…HBO therapy can be applied to patients who underwent RT and require extractions 32,33 . Marx in 1985 established a protocol consisting of 20 dives of HBO before extraction and 10 dives after, advocating that HBO increases tension and diffusion of oxygen, collagen synthesis, and vascular network consequently healing the tissue 33 .…”

Section: Hbo Therapy In Preventionmentioning

confidence: 99%

“…However, it depends on the quality of the studies reviewed. There are systematic reviews regarding the incidence and prevention of ORN 32,34,35,37 . However, most studies included are retrospective analysis and represent weak evidence.…”

Section: Final Considerationsmentioning

confidence: 99%

Maxillary osteoradionecrosis – review of published literature: incidence, classification, risk factors, physiopathology and prevention

Berthold

Zanella²,

Heitz³

2013

Rev. da Fac. de Odontologia, UPF

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“…Marx reported 6) that the pathophysiological feature of ORN was represented by hypoxia, hypovascularization and hypocellularity (3-H concept). HBO is believed to improve these poor biological conditions by inducing angiogenesis 7,8) and stem cell mobilization 9) , thus resulting in enhanced wound healing [9][10][11] . Since Henk's first application of HBO to ORNJ in the 1960s 12) , there has been numerous reports of the effectiveness of HBO on ORNJ 10,11) .…”

Section: Introductionmentioning

confidence: 99%

“…HBO is believed to improve these poor biological conditions by inducing angiogenesis 7,8) and stem cell mobilization 9) , thus resulting in enhanced wound healing [9][10][11] . Since Henk's first application of HBO to ORNJ in the 1960s 12) , there has been numerous reports of the effectiveness of HBO on ORNJ 10,11) . ORNJ was recognized as an indication for HBO in "delayed radiation injury (soft tissue and bony necrosis) in the 2003 Undersea Hyperbaric Medical Society Committee Report (UHMS) 13) .…”

Section: Introductionmentioning

confidence: 99%

The Influence of Radiation Therapy and Hyperbaric Oxygen Therapy on Osteoradionecrosis of the Jaw

Ohba¹,

Yoshimura²,

Kobayashi³

et al. 2013

J. Hard Tissue Biology.

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The object of this study was to estimate the influence of radiation therapy (RT) and hyperbaric oxygen therapy (HBO) on osteoradionecrosis of the jaw (ORNJ). This retrospective study included patients who were diagnosed with ORNJ from 1998 to 2012 (15 years) and who recieved a total dose of RT (Gy) for the duration of the study. The duration of ORNJ development and the healing period of ORNJ were examined. The mean dose of RT was 64.0 Gy. The mean healing period of ORNJ was 30.3 months in the continuous RT group, and 20.8 months in the pre-and post-operative irradiation group. The healing term for ORNJ with HBO was approximately the same as that without HBO. We concluded continuous RT may induce more severe ORNJ than pre-and postoperative RT, and that the effectiveness of HBO on ORNJ is suspicious.

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Hyperbaric Oxygen Therapy in the Management of Radiation-Induced Injury in the Head and Neck Region: A Review of the Literature

Cited by 52 publications

References 63 publications

Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

Maxillary osteoradionecrosis – review of published literature: incidence, classification, risk factors, physiopathology and prevention

The Influence of Radiation Therapy and Hyperbaric Oxygen Therapy on Osteoradionecrosis of the Jaw

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