Hyperbaric Oxygen Therapy Induces Kidney Protection in an Ischemia/Reperfusion Model in Rats

Ramalho, Rodrigo José; Pv, Oliveira; Cavaglieri, Rita C.; Silva, C.; Medeiros, Paulo José de; Filho, D. Martini; Poli-de-Figueiredo, Luiz Francisco; Noronha, Irene L.

doi:10.1016/j.transproceed.2012.07.020

Cited by 18 publications

(12 citation statements)

References 13 publications

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“…Significant decreases in Cr (3.8 ± 0.2 vs. 2.7 ± 0.1 mg/dL) and BUN (120 ± 2.2 vs. 105 ± 2.5 mg/dL) were found 24 hours after renal I/R injury between the I/R and I/R + HBO groups, respectively. These results were matched with another study of Ramalho et al ( 14 ) describing the significantly lower levels of Cr and BUN, suggesting that HBO therapy ameliorated renal function after the injury.…”

Section: Discussionsupporting

confidence: 88%

“…Reperfusion is vital for the ischemic renal tissue but has the potential to aggravate tissue injury ( 12 ). Several studies have shown the beneficial effects of HBO on the histopathological changes after renal I/R ( 13 , 14 ). Cellular death that occurs after I/R injury was morphologically divided into apoptosis and necrosis, both of which are positioned as different types of cellular death ( 15 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

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Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats

et al. 2016

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Background:Renal ischemia/reperfusion (I/R) injury remains a major cause of acute kidney injury (AKI), in addition to I/R injury-induced tissue inflammation, necrosis and apoptosis. Hyperbaric oxygen therapy (HBO) is defined as a treatment in which a patient is intermittently exposed to 100% oxygen pressurized to a pressure above sea level (> 2.0 atmospheres absolute (ATA), 1.0 ATA = 760 mmHg). It has been used in a number of medical conditions with a proven efficacy in a limited number of disorders. However, the effects of HBO therapy on apoptosis and proliferative activity after I/R injury have not been fully understood.Objectives:We studied the possible beneficial effects of HBO therapy on apoptosis and tubular cell regeneration after renal I/R injury in rats.Materials and Methods:Sprague-Dawley (SD) rats were randomized into three groups: Sham (Sham-operated rats); I/R (animals submitted to I/R); and I/R + HBO (I/R rats exposed to HBO). Tubular cell apoptosis was confirmed by DNA laddering and the terminal deoxynucleotidyl transferase-mediated uridine triphosphate nick end labeling (TUNEL) assay. Cellular proliferation activity was determined using the anti-Ki-67 antibody.Results:A significant decrease in apoptotic cells and increase in proliferative reaction were observed in the I/R + HBO group compared to the I/R group.Conclusions:We demonstrated that HBO suppressed apoptosis, which caused inflammation after renal I/R, and promoted tubular cell regeneration. HBO has protective effects against AKI caused by renal I/R through the inhibition of apoptosis.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats

et al. 2016

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“…13,15,16 In this regard, it is interesting to note that hyperbaric oxygen has been shown to exert a protective effect in an ischemia/reperfusion model in the rat. 18 …”

mentioning

confidence: 99%

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

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Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.

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“…Исследования, посвященные влиянию ГБО в посттрансплантационном периоде, заслуживающие, по нашему мнению особого внимания, в основном представлены модельными экспериментами на животных. Например, был показан положительный эффект при трансплантации фрагментов кости у кроликов [52], островковых клеток поджелудочной железы у мышей [36,53], ишемически-реперфузионном повреждении почки у крыс [29,[54][55][56], ишемически-реперфузионном повреждении печени у крыс [57] и регенерации печени у крыс после ее резекции [58,59]. Кроме того, ГБО сопровождается увеличением синтеза фактора роста эндотелия сосудов (VEGF) [36,60], индукцией толерантности [28] и повышением выживаемости трансплантата [33,61].…”

Section: гипербарическая оксигенация в посттрансплантационном периодеunclassified

Hyperbaric oxygenation in transplantology

Левина¹,

Евсеев²,

Хубутия³

et al. 2020

Transplantologiâ (Mosk.)

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The ability to eliminate any form of oxygen debt by transporting oxygen to organs and tissues, by dissolving it in body fluids, brings hyperbaric oxygenation to a new level of application in transplantology. The review discusses the pathophysiological aspects of hyperbaric oxygenation during ischemia and reinfusion, especially when used in transplantology, and also investigations on the use of hyperbaric oxygenation in model experiments and in clinical practice. Analysis of the efficacy of hyperbaric oxygenation therapy at various stages of the transplantation process (preconditioning, donation, organ storage, in the early and late post-transplant periods) allows us to conclude that this method should be more widely involved in transplantation practice.Authors declare no conflict of interest.

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Hyperbaric Oxygen Therapy Induces Kidney Protection in an Ischemia/Reperfusion Model in Rats

Cited by 18 publications

References 13 publications

Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats

Hyperbaric Oxygen Therapy Suppresses Apoptosis and Promotes Renal Tubular Regeneration After Renal Ischemia/Reperfusion Injury in Rats

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Hyperbaric oxygenation in transplantology

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