Hyperbaric oxygen therapy of olfactory dysfunction in diabetic neuropathy with type 2 diabetes mellitus and a new definition Diabetic Olfactopathy

Veyseller, Bayram; Doğan, Remzi; Yenigün, Alper; Aksoy, Fadullah; Tuğrul, Selahattin; Doğan, Elif; Özturan, Orhan

doi:10.4193/rhin15.314

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…Bombin et al 1712 found that factors such as inflammation and duration of illness with SLE, as well as secondary anxiety and depression, usually mandates multidisciplinary evaluation in these patients. Another important cause of olfactory disorders among autoimmune diseases is IgG4‐related disease, which has been associated with type 1 autoimmune pancreatitis, chronic sialoadenitis, kidney disease, periaortitis, and dacryoadenitis 1713 . Yagi‐Nakanishi et al 1714 found that 52% of these patients had OD.…”

Section: Managementmentioning

confidence: 99%

International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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Section: Managementmentioning

confidence: 99%

International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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“…HBO is commonly used to treat diabetic foot ulcers and neuropathy in patients with diabetes mellitus ( 39 , 40 ). Treatment involves intermittent administration of 100% oxygen, usually in daily sessions of 60–90 min, at pressures of 1.5–3.0 ATA ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Ghrelin system is involved in improvements in glucose metabolism mediated by hyperbaric oxygen treatment in a streptozotocin‑induced type�1 diabetes mouse model

et al. 2020

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Type 1 diabetes mellitus (T1dM) is an autoimmune disorder for which the only effective therapy is insulin replacement. Hyperbaric oxygen (HBo) therapy has demonstrated potential in improving hyperglycemia and as a treatment option for T1dM. Ghrelin and HBo have been previously reported to exert proliferative, anti-apoptotic and anti-inflammatory effects in pancreatic cells. The present study investigated the mechanism underlying HBo-and ghrelin system-mediated regulation of glucose metabolism. Male c57Bl/6 mice were intraperitoneally injected with streptozotocin (STZ; 150 mg/kg) to induce T1dM before the diabetic mice were randomly assigned into the T1dM and T1dM + HBo groups. Mice in the T1dM + HBo group received HBo (1 h; 100% oxygen; 2 atmospheres absolute) daily for 2 weeks. Significantly lower blood glucose levels and food intake were observed in mice in the T1dM + HBo group. Following HBo treatment, islet β-cell area were increased whereas those of α-cell were decreased in the pancreas. in addition, greater hepatic glycogen storage in liver was observed, which coincided with higher pancreatic glucose transporter 2 (GluT2) expression levels and reduced hepatic GluT2 membrane trafficking. There were also substantially higher total plasma ghrelin concentrations and gastric ghrelin-o-acyl transferase (GoaT) expression levels in mice in the T1dM + HBo group. HBo treatment also abolished reductions in pancreatic GoaT expression levels in T1dM mice. additionally, hepatic growth hormone secretagogue receptor-1a levels were found to be lower in mice in the T1dM + HBo group compared with those in the T1dM group. These results suggest that HBo administration improved glucose metabolism in a STZ-induced T1dM mouse model. The underlying mechanism involves improved insulin-release, glucose-sensing and regulation of hepatic glycogen storage, an observation that was also likely dependent on the ghrelin signalling system.

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“…These complications include but are not limited to diabetic foot ulcers, diabetic olfactopathy, cervical necrotizing fasciitis of odontogenic origin, and diabetes related atherosclerosis. 6 , 23 , 24 , 27 To our best knowledge, there is only one preclinical study, which evaluated the effectiveness of the HBO treatment on implant osseointegration in diabetic subjects. 18 The study was conducted in the tibiae of rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyperbaric oxygen treatment on implant osseointegration in experimental diabetes mellitus

et al. 2018

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Objective To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointegration in diabetic rabbits.Material and Methods An experimental diabetes model was induced in 32 New Zealand rabbits through IV injection of alloxan. After the state of diabetes had been confirmed, one dental implant was placed in the metaphysical region of each animal’s tibia. After the implants’ placements, the animals were divided into two groups. Half of the animals underwent HBO treatment, while the other group did not receive HBO treatment and served as the control group. The animals were euthanized at the 4th and 8th weeks. The osseointegration of the implants were compared by histomorphometry and resonance frequency analysis (RFA).Results The Bone Implant Contact (BIC) values were significantly higher in the HBO group than in the control group at the 4th week. There was no difference in the BIC values between the groups at the 8th week. There was no significant difference in the RFA scores between the groups both at the 4th and 8th weeks after the operation.Conclusion Histomorphometry findings suggest that HBO has positive effect on implant osseointegration in the early healing period in diabetic rabbits. However, implant stability is not affected by HBO treatment.

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Hyperbaric oxygen therapy of olfactory dysfunction in diabetic neuropathy with type 2 diabetes mellitus and a new definition Diabetic Olfactopathy

Cited by 7 publications

References 28 publications

International consensus statement on allergy and rhinology: Olfaction

International consensus statement on allergy and rhinology: Olfaction

Ghrelin system is involved in improvements in glucose metabolism mediated by hyperbaric oxygen treatment in a streptozotocin‑induced type�1 diabetes mouse model

Effects of hyperbaric oxygen treatment on implant osseointegration in experimental diabetes mellitus

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