Hyperbaric oxygen therapy reduces astrogliosis and helps to recovery brain damage in hydrocephalic young rats

Silva, Stephanya Covas da; Féres, Omar; Beggiora, Pâmella da Silva; Machado, Hélio Rubens; Reis, Rafael de Menezes; Araujo, João Eduardo de; Brandão, Ricardo; Lopes, Luíza da Silva

doi:10.1007/s00381-018-3803-0

Cited by 10 publications

(7 citation statements)

References 46 publications

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“…This may be due to lower peak levels of oral therapy than after parenteral administration. In other studies, hydrocephalic young rats treated with hyperbaric oxygen therapy performed better on behavioral tests than untreated rats, although there was no significant effect on ventricular dilation ( da Silva et al, 2018 ). Silva et al suggested that hyperbaric oxygen therapy may promote functional recovery of the CNS by inhibiting the activation of astrocytes and forming an extensive fibrillar network, in addition to its own antioxidant stress effect ( da Silva et al, 2018 ; Supplementary Table 1 ).…”

Section: Therapeutic Targeting Of Astrocytes For the Treatment Of Hyd...mentioning

confidence: 88%

Novel therapeutic modulators of astrocytes for hydrocephalus

Yang

Wang²,

Chen³

et al. 2022

Front. Mol. Neurosci.

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Hydrocephalus is mainly characterized by excessive production or impaired absorption of cerebrospinal fluid that causes ventricular dilation and intracranial hypertension. Astrocytes are the key response cells to inflammation in the central nervous system. In hydrocephalus, astrocytes are activated and show dual characteristics depending on the period of development of the disease. They can suppress the disease in the early stage and may aggravate it in the late stage. More evidence suggests that therapeutics targeting astrocytes may be promising for hydrocephalus. In this review, based on previous studies, we summarize different forms of hydrocephalus-induced astrocyte reactivity and the corresponding function of these responses in hydrocephalus. We also discuss the therapeutic effects of astrocyte regulation on hydrocephalus in experimental studies.

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Section: Therapeutic Targeting Of Astrocytes For the Treatment Of Hyd...mentioning

confidence: 88%

Novel therapeutic modulators of astrocytes for hydrocephalus

Yang

Wang²,

Chen³

et al. 2022

Front. Mol. Neurosci.

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“…In the meantime, it has been revealed that HBO therapy showed promising effects in ameliorating neurological deficits after TBI [ 8 , 9 ]. In recent years, accumulating evidences indicated that HBO therapy not only promotes the repair of wounds, but also inhibits the excessive proliferation of glial cells, attributed greatly due to its distinctive character to inhibit scar formation, thereby facilitating the neurological repair on this basis [ 10 , 11 ]. However, the mechanisms through which HBO therapy exerts its neuroprotective role remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Role of hyperbaric oxygen therapy in PDGF-BB-mediated astrogliosis in traumatic brain injury rats associated with ERK1/2 signaling pathway inhibition

Xiu

et al. 2023

Eur J Med Res

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Background Hyperbaric oxygen (HBO) plays positive roles in the therapy of traumatic brain injury (TBI); however, the mechanism underlying its effects on TBI is largely unknown. The study aims to elucidate the molecular mechanism implicated with the interaction between platelet-derived growth factor-BB (PDGF-BB) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway, which may play critical roles during HBO treatment both in the astrocyte scratching model in vitro and rat TBI model in vivo. Methods Changes in neurological function and wound healing were evaluated using the neurological severity scores (NSS) scale, immunohistochemistry, western blotting, and qRT-PCR, respectively. Results The results showed that PDGF-BBi (PDGB interfered with small RNA) dramatically improves neuronal viability in vitro when transfected into the scratched astrocytes derived from the cerebral cortex of neonatal rats. Moreover, in vivo experiments revealed that HBO therapy substantially elevated the NSS scores and simultaneously reduced the mortality in TBI rats, as indicated by the NSS scales. Notably, HBO therapy was found to possess the ability to inhibit glial cell proliferation, promote the regeneration of neurons and synapses, and ultimately facilitate the wound healing, as revealed by immunohistochemistry and glial scar formation found in TBI rats. Importantly, HBO markedly decreased the expression levels of PDGF-BB and ERK1/2. It can clearly be seen that downregulated PDGF-BB and ERK1/2 levels were corresponding with the status of significant amelioration of the therapeutic effect of HBO. Conversely, the upregulation of PDGF-BB and ERK1/2 levels was in line with the opposite effect. Conclusion It has been concluded that HBO therapy may play its active role in TBI treatment dependent on astrogliosis inhibition, which may be achieved by downregulating the ERK1/2 signaling pathway mediated by PDGF-BB.

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“…Os astrócitos são os principais responsáveis pelo reparo celular neuronal após lesão, e a GFAP é um marcador de astrócitos maduros. A presença dessas células a longo prazo leva a alterações estruturais (cicatrizes) e metabólicas no hipocampo, que barram a recuperação da função cognitiva (85,112). O processo de cicatrização neuronal não é completamente entendido, mas estima-se que os astrócitos possam se diferenciar em células progenitoras multipotentes (113).…”

Section: Discussionunclassified

“…A avaliação da histologia feita através do escore de lesão histológica intestinal apresentou valores médios de 0,20 para o grupo C, 0,96 para o grupo COHB1 e de 0, 85…”

Section: Graduação Histológica De Lesão Intestinalunclassified

Efeito da oxigenoterapia hiperbárica sobre o intestino e o cérebro de ratos submetidos a modelo experimental de enterocolite necrosante

Dalto

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Hyperbaric oxygen therapy reduces astrogliosis and helps to recovery brain damage in hydrocephalic young rats

Cited by 10 publications

References 46 publications

Novel therapeutic modulators of astrocytes for hydrocephalus

Novel therapeutic modulators of astrocytes for hydrocephalus

Role of hyperbaric oxygen therapy in PDGF-BB-mediated astrogliosis in traumatic brain injury rats associated with ERK1/2 signaling pathway inhibition

Efeito da oxigenoterapia hiperbárica sobre o intestino e o cérebro de ratos submetidos a modelo experimental de enterocolite necrosante

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