Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model

Sönmez, Alper; Yılmaz, Mahmut İlker; Korkmaz, Ahmet; Topal, Turgut; Çağlar, Kayser; Kaya, Ayper; Eyıleten, Tayfun; Yenicesu, Müjdat; Oğuz, Yusuf; Başal, Şeref; İpçioğlu, Osman Metin; Vural, Abdülgaffar

doi:10.1007/s10157-007-0017-2

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…GPX may play an important role in the protection of extracellular fluid component and cell surface against peroxide mediated damage; in this sense, any reduction in its activity will therefore result in increased lipid peroxidation. Studies with humans (Ceballos-Picot et al, 1996;Zachara et al, 2004Zachara et al, , 2006 and animals (Sonmez et al, 2008) indicate a gradual decrease in GPX activity with progression of the renal disease possibly due to the fact that this enzyme is synthesized predominantly in the kidney. Our results showed no significant change in GPX activity after renal injury, but a significant increase in activity was observed in animals with CKD exposed to exercise (Fig.…”

Section: Discussionmentioning

confidence: 95%

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

et al. 2012

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Section: Discussionmentioning

confidence: 95%

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

et al. 2012

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“…In experimental nephrology (rats), HBOT has been used in acute kidney injury and ischemia/reperfusion models, cisplatin-and cyclosporine-related nephrotoxicity, and nephrotic syndrome [32][33][34][35]. In clinical nephrology, HBOT was used in cutaneous ulcers due to calciphylaxis, chronic osteomyelitis, hemorrhagic cystitis, and renal zygomycosis [36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy in a patient with autosomal dominant polycystic kidney disease with a perinephritic abscess

et al. 2010

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A 68-year-old female in hemodialysis due to autosomal dominant polycystic kidney disease underwent resection of cysts in her right kidney via a laparoscopic approach due to abdominal pain. Three weeks after surgery, she was admitted with sepsis. A CT scan showed a large abscess around the right kidney. Percutaneous drainage of abscess was performed. The pus smear showed Gram-positive cocci and the culture contained methicillin-resistant Staphylococcus aureus. Ciprofloxacin, clindamycin and vancomycin were given. In the 3 weeks following admission, she remained febrile and septic and showed a progressive deterioration in her general condition, along with malnutrition and persistent drainage of purulent material from her right flank. The antibiotic therapy was changed to vancomycin, metronidazole and meropenem, but no improvement was observed. Because of the high risk associated with carrying out an open nephrectomy, we decided to use hyperbaric oxygen therapy (HBOT) as a potentially useful measure to control her infection. The patient underwent 26 daily sessions of 100% hyperbaric oxygen (2.5 atm). The use of HBOT induced a notable break in the clinical course of this patient's retroperitoneal infection. She was discharged after day 58 without any signs of inflammatory activity, and she has not presented reactivation of infection since then. We think that this case suggests that this therapy could be a new therapeutic tool in the management of patients with similar clinical features when all other therapeutic measures have failed. We did not find any other reports of the use of HBOT in infections of renal cysts.

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“…Yilmaz et al found that HBOT has a synergistic effect with an angiotensin receptor blocker to reduce proteinuria in the adriamycin rodent model of focal segmental glomerulosclerosis (FSGS) [5]. Sonmez et al found the same with an angiotensin-converting enzyme inhibitor [6]. Several studies in rat models of ischemia perfusion injury found beneficial effects of HBOT on histological and biochemical markers of injury.…”

Section: Discussionmentioning

confidence: 99%

“…ese same factors are implicated in the pathogenesis of microvascular complications of diabetes in the eye and in the kidney [3]. is suggests HBOT might be potentially harmful for patients with diabetes; however, animal studies show reduced proteinuria with HBOT treatments [4][5][6]. Virtually, no clinical data exist on the effect of HBOT on proteinuria and renal function in patients with diabetes mellitus, despite its widespread use in these patients.…”

Section: Introductionmentioning

confidence: 99%

Renal Effects of Hyperbaric Oxygen Therapy in Patients with Diabetes Mellitus: A Retrospective Study

Sedlacek

Harlan

Buckey

2021

International Journal of Nephrology

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Hyperbaric oxygen therapy (HBOT) is an adjunctive treatment for patients with diabetic foot ulcers. The prolonged high oxygen level used in HBOT can produce oxidative stress, which may be harmful to the kidney. Animal experiments suggest HBOT does not harm renal function and may have an antiproteinuric effect, but little is known on the effect of HBOT in humans. We performed a retrospective chart review of 94 patients with diabetes mellitus who underwent HBOT at our institution over an eight-year period. Thirty-two patients had serum creatinine levels within 60 days of the start and the end of treatment. Creatinine levels were 1.41 ± 0.89 mg/dl before and 1.52 ± 1.17 mg/dl after hyperbaric treatments with no statistically significant difference (mean (postcreatinine + precreatinine/2) = 0.10 mg/dl, SE = 0.11, t = 0.89). Twenty-three patients had proteinuria measurements before and after HBOT mainly by urine dipstick analysis. A Wilcoxon signed-rank test showed less proteinuria after HBOT than before (N = 23, p = 0.002 ). Proteinuria was absent in 7 of 23 patients (30%) before HBOT and 13 of 23 patients (57%) after HBOT, a reduction by almost 50%. This observation is remarkable because oxidative stress might be expected to increase rather than decrease proteinuria.

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Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model

Abstract: Both cilazapril and simvastatin regimens improve oxidative stress and proteinuria, while the effects significantly increase with the combination of HBO treatment. HBO seems to be a candidate antioxidant strategy in glomerular diseases.

Cited by 8 publications

References 37 publications

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

Hyperbaric oxygen therapy in a patient with autosomal dominant polycystic kidney disease with a perinephritic abscess

Renal Effects of Hyperbaric Oxygen Therapy in Patients with Diabetes Mellitus: A Retrospective Study

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