Hyperbaric Oxygen Treatment Improves Intestinal Barrier Function After Spinal Cord Injury in Rats

Liu, Xuehua; Liang, Fang; Zhang, Jing; Li, Zhuo; Yang, Jing; Kang, Nan

doi:10.3389/fneur.2020.563281

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…Intestinal epithelial barrier dysfunction has proved after SCI (Liu et al, 2020(Liu et al, , 2021. The change leads to more opportunities for bacteria and their metabolites to enter the circulation, cause enterogenous infection, and further lead to the disorder of flora.…”

Section: Changes In Intestinal Epithelial Barrier Dysfunctionmentioning

confidence: 99%

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Zhang

Lang²,

Guo³

et al. 2022

Front. Neurosci.

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Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment.

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Section: Changes In Intestinal Epithelial Barrier Dysfunctionmentioning

confidence: 99%

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Zhang

Lang²,

Guo³

et al. 2022

Front. Neurosci.

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“…The findings regarding parameters linked to vascular signaling and stress confirmed that HBO counteracts hypoxia by improving oxygen delivery to areas with diminished blood flow. HBO reduces oxidative stress by means of the upregulation of scavengers, SOD [ 28 , 29 , 30 ], and interferes with neutrophil adhesion to endothelia while enhancing cell-to-cell interaction at the level of tight- and gap junctions [ 31 , 32 ]. In case of impaired microcirculation, microvascular dynamics are improved by counteracting vasoconstriction, in part based on enhancement of the production of NO [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair

Lindenmann

Smolle

Kamolz

et al. 2021

IJMS

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For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of indications involving tissue repair. These indications comprise a wide range of diseases ranging from intoxications to ischemia-reperfusion injury, crush syndrome, central nervous injury, radiation-induced tissue damage, burn injury and chronic wounds. In a systematic review, the molecular mechanisms triggered by HBO described within the last two decades were compiled. They cover a wide range of pathways, including transcription, cell-to-cell contacts, structure, adhesion and transmigration, vascular signaling and response to oxidative stress, apoptosis, autophagy and cell death, as well as inflammatory processes. By analyzing 71 predominantly experimental publications, we established an overview of the current concepts regarding the molecular mechanisms underlying the effects of HBO. We considered both the abovementioned pathways and their role in various applications and indications.

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“…They interact with the cytoskeleton, regulating smooth muscle tone, and regulating shape, migration and cell-to-cell adhesion. In particular, Rho-proteins influence the actin cytoskeleton, and thereby, smooth muscle tone regulation and seem to be important for modulating tight-junction protein function [ 58 , 59 ].…”

Section: Hyperbaric Oxygen and Regenerationmentioning

confidence: 99%

“…Following spinal cord injury intestinal mucosal injury score, intestinal permeability, and levels of Rho and ROCK1 were higher, whereas tight junction proteins were significantly lower than in controls. HBO downregulated the expression of Rho and ROCK1, whilst the expression of the junctional proteins Occludin and ZO-1 was elevated yielding decreased intestinal permeability while intestinal mucosal injury declined significantly [ 59 ].…”

Section: Hyperbaric Oxygen and Regenerationmentioning

confidence: 99%

Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey

Lindenmann

Kamolz

Graier³

et al. 2022

Biomedicines

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By addressing the mechanisms involved in transcription, signaling, stress reaction, apoptosis and cell-death, cellular structure and cell-to-cell contacts, adhesion, migration as well as inflammation; HBO upregulates processes involved in repair while mechanisms perpetuating tissue damage are downregulated. Many experimental and clinical studies, respectively, cover wound healing, regeneration of neural tissue, of bone and cartilage, muscle, and cardiac tissue as well as intestinal barrier function. Following acute injury or in chronic healing problems HBO modulates proteins or molecules involved in inflammation, apoptosis, cell growth, neuro- and angiogenesis, scaffolding, perfusion, vascularization, and stem-cell mobilization, initiating repair by a variety of mechanisms, some of them based on the modulation of micro-RNAs. HBO affects the oxidative stress response via nuclear factor erythroid 2-related factor 2 (Nrf2) or c-Jun N-terminal peptide and downregulates inflammation by the modulation of high-mobility group protein B1 (HMGB-1), toll-like receptor 4 and 2 (TLR-4, TLR-2), nuclear factor kappa-B (NFκB), hypoxia-inducible factor (HIF-1α) and nitric oxide (NO•). HBO enhances stem-cell homeostasis via Wnt glycoproteins and mammalian target of rapamycin (mTOR) and improves cell repair, growth, and differentiation via the two latter but also by modulation of extracellular-signal regulated kinases (ERK) and the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway. The HBO-induced downregulation of matrix metalloproteinases-2 and 9 (MMP-2/-9), rho-associated protein kinase (ROCK) and integrins improve healing by tissue remodeling. Interestingly, the action of HBO on single effector proteins or molecules may involve both up- or downregulation, respectively, depending on their initial level. This probably mirrors a generally stabilizing potential of HBO that tends to restore the physiological balance rather than enhancing or counteracting single mechanisms.

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Hyperbaric Oxygen Treatment Improves Intestinal Barrier Function After Spinal Cord Injury in Rats

Cited by 7 publications

References 38 publications

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair

Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey

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