Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft‐tissue infection

Abstract

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Effect of immunoglobulin G on cytokine response in necrotising soft‐tissue infection: A post hoc analysis

“…G‐CSF is a pro‐inflammatory cytokine suggested to be involved in sepsis pathogenesis and to promote important functions on mature myeloid cells and the innate immune system 27,28 . It was recently associated with disease severity and 30‐day mortality in an observational study including 242 NSTI patients, 20 but we observed no apparent effect of IVIG on G‐CSF.…”

“…This was a post hoc analysis of the INSTICT trial; a single‐centre randomised, blinded, placebo‐controlled trial performed from February 2014 to March 2016 at Rigshospitalet, University of Copenhagen 16 . The cytokine measurements were made available for the present post hoc analysis, as these previously have been evaluated in a larger observational setting which partly included the INSTICT trial 20 …”

“…This is a post hoc analysis of the INSTICT trial (ClinicalTrials.gov; NCT02111161) 16 , which was approved by the Regional Ethics Committee of the Capital Region Denmark and the Danish Medicines Agency. Additionally, the cytokine study was approved by the Regional Ethical Committee of Capital Region (H‐19016085) and the Danish Data Protection Agency (VD‐2019‐179) 20 …”

“…16 The cytokine measurements were made available for the present post hoc analysis, as these previously have been evaluated in a larger observational setting which partly included the INSTICT trial. 20…”

Hyperbaric oxygen therapy as adjuvant therapy for odontogenic necrotizing myositis: A case report

“…22,23 Finally, HBOT has shown to induce substantial effects on the expression of immune modulatory cytokines by decreasing pro-inflammatory cytokines such as IL-1, IL-6, and TNF-alfa and elevating the anti-inflammatory cytokine IL-10. 24 It is interesting to report other effects that HBOT is able to exert on wounds as it encourages collagen production by fibroblast, which leads to the growth of granulation tissue, an essential step in wound healing. 25 Moreover, the increase in oxygen tension, which persists for several hours after therapy, is responsible for angiogenic properties of HBOT.…”