Hyperbranched polysiloxane-based probe with enhanced lipophilicity for visualizing ONOO− fluctuations in endoplasmic reticulum

Highly selective and sensitive surface-enhanced Raman scattering sensors for the detection of peroxynitrite in cells

“…At present, several methods for detecting ONOO − have been reported, such as near-infrared spectroscopy, 17,18 high-performance liquid chromatography, 19 chemiluminescence, 20 fluorescence spectroscopy, 21–23 ultraviolet-visible absorption spectroscopy, 24 electron spin resonance 25,26 and electrochemistry. 27,28 Although there have been a few reports on SERS methods for detecting intracellular ONOO − , 29 the reasons of ONOO − causing organisms lesions have not well explained yet.…”

“…In addition, an abnormally high level of ONOO − is also related to many diseases, such as neurodegenerative diseases, 8,9 inflammatory infections, 10,11 liver injury diseases, 12,13 and even cancer, 14 as well as influencing the endoplasmic reticulum viscosity. 15,16 At present, several methods for detecting ONOO − have been reported, such as near-infrared spectroscopy, 17,18 high-performance liquid chromatography, 19 chemiluminescence, 20 fluorescence spectroscopy, [21][22][23] ultraviolet-visible absorption spectroscopy, 24 electron spin resonance 25,26 and electrochemistry. 27,28 Although there have been a few reports on SERS methods for detecting intracellular ONOO − , 29 the reasons of ONOO − causing organisms lesions have not well explained yet.…”

A Small-Molecule Fluorescent Probe for the Detection of Mitochondrial Peroxynitrite

“…•− , which then reacts with the target molecules [6][7][8]. Therefore, ONOO − can destroy many important biomolecules (such as nucleic acids, proteins, and lipids) [9][10][11][12][13]. These biochemical properties make ONOO − an important predisposing factor for many diseases, including cardiovascular diseases, neurodegenerative diseases, inflammatory diseases, and cancer [14][15][16][17][18][19].…”