Hypercalcemia in Association With Cutaneous Squamous Cell Carcinoma

Hypercalcemia associated with squamous cell carcinoma arising in pyoderma chronica

“…[6][7][8] In one case complicated with pyoderma chronica, calcium level was well controlled by chemotherapy. 2 In our case, because increased serum PTHrP and hypercalcemia with concomitant decrease in serum PTH and phosphorus levels was improved after the combination therapy temporarily, the major cause of hypercalcemia is most likely due to the PTHrP secreted by the tumor.…”

“…The prognosis of hypercalcemia is also poor; approximately 75% of cases died within 3 months following the treatment 5 . There are 10 reports of humoral hypercalcemia of malignancy in association with primary cutaneous SCC 2,6–9 …”

“…Malignant transformation of pyoderma chronica is rarely observed. 1,2 It tends to be more locally aggressive than the usual cutaneous SCC with higher incidence of distant metastasis and poor prognosis. Maclean and Coleman 3 reported that 15 out of 31 cases of pyoderma chronica-related SCC died within 2 years following the diagnosis of SCC.…”

“…Pyoderma chronica, synonymous to acne conglobata and hidradenitis suppurativa, is a chronic suppurative scarring disease which typically involves buttocks, perianal and anogenital regions. Malignant transformation of pyoderma chronica is rarely observed 1,2 . It tends to be more locally aggressive than the usual cutaneous SCC with higher incidence of distant metastasis and poor prognosis.…”

Squamous Cell Carcinoma Arising in Hidradenitis Suppurativa

“…One year later Jackman 11 found 4 cases of squamous cell carcinoma out of 125 cases of hidradenitis suppurativa. A small number of cases has been published since 1,8,12–16 . The main clinical data on those we could find are summarized on Table 1.…”