Hypercalcemia in Squamous Cell Carcinoma of the Skin

Makoui, Cyrus

doi:10.1001/jama.1978.03280450054026

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…Hypercalcemia in squamous cell carcinoma of other organs has also been described [12,13], however, squa mous cell carcinoma of the skin associated with hypercalcemia without bone metastasis or hyperparathyroidism is extremely rare. Only four cases have been reported so far [1,3,6,11]. Leukocytosis was noted in cases of Armati et al and Sparks et al, but not in others.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma with Hypercalcemia and Leukocytosis

et al. 1986

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Squamous cell carcinoma with hypercalcemia and leukocytosis arising from burn scars in a 45-year-old man is reported. Hypercalcemia and leukocytosis improved with pepleomycin treatment and worsened with recurrence of the tumor. Serum levels of parathyroid hormone, prostaglandin E and 25-OH-Vitamin D were within normal limits. Autopsy did not disclose any bone metastases or abnormalities of the parathyroid glands. It is suggested that hypercalcemia and leukocytosis were due to factors produced by the squamous cell carcinoma. This is the fifth reported case of cutaneous squamous cell carcinoma associated with hypercalcemia in the absence of bone metastasis or parathyroid gland abnormalities.

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Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma with Hypercalcemia and Leukocytosis

et al. 1986

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“…By evaluating the title/abstract information of the initially returned 831 papers we localized 53 articles with potentially relevant content for full-text search ( Figure 1 ). Of them, 15 were excluded (one was a duplicate publication, seven were cases of penile SCC, six were erroneously identified as reporting PNS in KSC and one reported no adequately personalized data) leaving to 39 papers reporting a total of 44 PNS cases associated with KSC [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. One paper ([ 47 ]) referred to five cases with relevant findings, however without any personalized data, and was excluded from this compilation, resulting in 38 papers reporting 39 relevant cases.…”

Section: Methodsmentioning

confidence: 99%

Paraneoplastic Syndromes in Patients with Keratinocyte Skin Cancer

Vlachos

Tziortzioti

Bassukas

2022

Cancers

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A variety of well-characterized cutaneous paraneoplastic syndromes (PNS) are diagnosed during internal malignancies; however, the spectrum of keratinocyte skin neoplasms (KSC) related to PNS is still obscure. The aim of the present review is to compile and evaluate the literature data on PNS associated with a keratinocyte skin neoplasm (KSC). Employing Pubmed, MEDLINE was searched for KSC-associated PNS reports. Forty relevant entries were assembled, reporting a total of 41 PNS cases associated with a KSC (34 male). No review paper compiling this topic was found. Six distinct PNS entities were identified, and malignancy associated hypercalcemia (MAH; 78%), anemia (10%) and Bazex syndrome (5%) were the most frequently reported among them. 85% of the PNS were reported in association with SCC, 10% with BCC, and the rest with adnexal tumors. The median age of the patients at the time of PNS diagnosis was 58 years (range: five–83 years). In most cases the PNS was diagnosed either concurrently or after the KSC diagnosis. KSC predisposing conditions, as scars (22%) or hidradenitis suppurativa (20%), were reported in >70% of the PNS cases. Most PNS resolved after KSC treatment. In conclusion, PNS of a rather limited spectrum of entities are reported in association with KSC. They also seem to be rare, possibly reflecting a limited capacity of KSC to provoke overt PNS.

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“…Depending upon the type of the tumor, hypercalcemia occurs in 20-30% of adult patients with malignancy during the course of the disease depending upon the type of the tumor [ 3 ]. Hypercalcemia in SCC of the skin is very rare [ 4 ]. In the pediatric population hypercalcemia is very rare and occurs only in 0.4-0.7% of childhood malignancies [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Denosumab Therapy for Refractory Hypercalcemia Secondary to Squamous Cell Carcinoma of Skin in Epidermolysis Bullosa

et al. 2015

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Hypercalcemia secondary to malignancy is rare in children and the majority is caused by tumor-produced parathyroid hormone-related protein (PTHrP). We report a case of hypercalcemia refractory to bisphosphonate and corticosteroid therapy, but responsive to denosumab. A 17-year-old boy with epidermolysis bullosa (EB) and advanced squamous cell carcinoma (SCC) of the left leg was referred with severe hypercalcemia (serum calcium, 4.2 mmol/L). The serum parathyroid hormone (PTH) was 0.7 pmol/L (1.1 - 6.9 pmol/L). The hypercalcemia was initially managed with hyperhydration, prednisolone and pamidronate. Following two infusions of pamidronate (1 mg/kg/dose), serum calcium fell to 2.87 mmol/L. However the hypercalcemia relapsed within a week (serum calcium, 3.61 mmol/L) needing aggressive management with intravenous fluids, prednisolone and two further doses of pamidronate. The serum calcium fell to 2.58 mmol/L over the first 4 days, but rose to 3.39 mmol/L 3 days later. As the hypercalcemia was refractory to bisphosphonate treatment, a trial dose of subcutaneous denosumab (60 mg) was administered following which the calcium fell to 2.86 mmol/L within 24 h and normocalcemia was sustained 4 days later. We report a case of refractory hypercalcemia secondary to malignant SCC, which responded well to denosumab therapy. To our knowledge, this is the first case of hypercalcemia of malignancy in an adolescent managed with denosumab.

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Hypercalcemia in Squamous Cell Carcinoma of the Skin

Cited by 8 publications

References 6 publications

Squamous Cell Carcinoma with Hypercalcemia and Leukocytosis

Squamous Cell Carcinoma with Hypercalcemia and Leukocytosis

Paraneoplastic Syndromes in Patients with Keratinocyte Skin Cancer

Denosumab Therapy for Refractory Hypercalcemia Secondary to Squamous Cell Carcinoma of Skin in Epidermolysis Bullosa

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