Hypercalcemia in the Emergency Department: A Missed Opportunity

Abstract

Primary hyperparathyroidism is surgically correctable and frequently presents with mild hypercalcemia. The symptoms of hyperparathyroidism are nonspecific often leading to a delay in diagnosis until patients present with an acute condition. Literature suggests that up to 20 per cent of patients presenting to the emergency department (ED) found to have hypercalcemia are ultimately diagnosed with hyperparathyroidism. We performed a retrospective review from 2012 to 2013 of patients with hypercalcemia in our ED and analyzed their characteristics. One hundred sixty-eight patients were identified with hypercalcemia. Patient medical history, chief complaint, review of symptoms, discharge disposition, and primary care physician (PCP) status were evaluated. Eighty-four per cent were classified as mild (10.8 to 11.9 mg/dL), 11 per cent as moderate (12 to 14 mg/dL), and five per cent as severe (greater than 14 mg/dL). A definitive diagnosis of hyperparathyroidism was identified in 3.5 per cent (six of 168). Documentation of hypercalcemia as a diagnosis was present in all patients in the severe and 78 per cent in the moderate categories. However, only 21 per cent of patients with mild hypercalcemia had documentation addressing this diagnosis. Of concern, 24 per cent (41 of 168) of patients were identified with mild hypercalcemia and discharged from the ED with no definitive plan based on lack of a PCP. Additionally, 81 per cent of these patients had symptoms referable to hypercalcemia. Mild hypercalcemia found during ED workup rarely requires immediate medical treatment. However, a significant number of those patients will have hyperparathyroidism amendable to surgical correction. Therefore, an appropriate mechanism for outpatient hypercalcemia workup should be integrated into the patient's ED discharge plan.

Calcium Disorders in the Emergency Department: Independent Risk Factors for Mortality

“…In a recent study, the cause of mild hypercalcaemia was only identified in 21% of patients [ 22 ]. In addition, only the minority of patients had a follow up or workup plan at discharge [ 22 ].…”

“…In a recent study, the cause of mild hypercalcaemia was only identified in 21% of patients [ 22 ]. In addition, only the minority of patients had a follow up or workup plan at discharge [ 22 ]. In contrast, the vast majority of these patients, symptoms related to hypercalcaemia could be found [ 22 ].…”

“…In addition, only the minority of patients had a follow up or workup plan at discharge [ 22 ]. In contrast, the vast majority of these patients, symptoms related to hypercalcaemia could be found [ 22 ]. Another study demonstrated that in patients with malignancy nearly half of patients showed symptoms of hypercalcaemia but in none of the medical reports was hypercalcaemia mentioned as the reason for hospitalization [ 23 ].…”