2021
DOI: 10.1016/s0378-4274(21)00717-7
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Hypercoagulability and cardiac injury are mitigated after cessation of waterpipe smoke exposure in mice

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(6 citation statements)
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“…Our data show IL1β, TNFα and IL17 concentrations were significantly augmented in the Reg-WPS but only IL17 was significantly augmented in Occ-WPS in heart homogenates. These results corroborate previous findings that showed that exposure to regular WPS elevated IL1β, IL6, and TNF-α levels in the heart (Nakhaee et al, 2019;Nemmar et al, 2019;Nemmar et al, 2023). Moreover, in vivo study has shown that exposure to WPS condensate increased the gene expression of IL1β and IL6 in lung cells (Zaarour et al, 2021).…”
Section: Discussionsupporting
confidence: 91%
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“…Our data show IL1β, TNFα and IL17 concentrations were significantly augmented in the Reg-WPS but only IL17 was significantly augmented in Occ-WPS in heart homogenates. These results corroborate previous findings that showed that exposure to regular WPS elevated IL1β, IL6, and TNF-α levels in the heart (Nakhaee et al, 2019;Nemmar et al, 2019;Nemmar et al, 2023). Moreover, in vivo study has shown that exposure to WPS condensate increased the gene expression of IL1β and IL6 in lung cells (Zaarour et al, 2021).…”
Section: Discussionsupporting
confidence: 91%
“…Our data show that either Occ-WPS or Reg-WPS exposure for 6mo caused an increase in the SBP compared with air-exposed mice, this effect was more pronounced and statistically significant in miceexposed to Reg-WPS. Consistent with this observation, we and others, have reported that exposure to WPS mice or rats increases SBP (Nemmar et al, 2013;Nemmar et al, 2017;Nemmar et al, 2019;Nemmar et al, 2023). These findings strongly suggest that there are no safe levels of WPS on blood pressure.…”
Section: Discussionsupporting
confidence: 90%
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