2024
DOI: 10.1002/ajh.27500
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Hypercoagulability in hemoglobinopathies: Decoding the thrombotic threat

Rayan Bou‐Fakhredin,
Maria Domenica Cappellini,
Ali T. Taher
et al.

Abstract: Beta (β)‐thalassemia and sickle cell disease (SCD) are characterized by a hypercoagulable state, which can significantly influence organ complication and disease severity. While red blood cells (RBCs) and erythroblasts continue to play a central role in the pathogenesis of thrombosis in β‐thalassemia and SCD, additional factors such as free heme, inflammatory vasculopathy, splenectomy, among other factors further contribute to the complexity of thrombotic risk. Thus, understanding the role of the numerous fact… Show more

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