Hypercoagulation state in infant with COVID-19: a case report

Abstract

Background: COVID-19 pandemic is not over yet, and the clinical manifestations of this newly emerged disease vary due to the rapid mutation of SARS-CoV-2 as its causative agent. The SARS-CoV-2 infection will stimulate the release of proinflammatory cytokines in large amounts, which further leads to hypercoagulation. The aim of this study is to describe a case of COVID-19 with hypercoagulation and what can be done to prevent serious complications. Case: 1.5-month-old baby boy presented with a complaint of coughing for 10 days. It was accompanied by persistent fever, diarrhea, and vomiting, but no shortness of breath or rhinorrhea was reported. It was known that his parents, whom he was living with, were self–isolating due to COVID – 19. On physical examinations, his vital signs were within normal limits except for axillary temperature, which was tested at 38.3°C. Laboratory results showed a prolongation of coagulation time (PT: 8,3 seconds, APTT: 23,2 seconds), elevated D-Dimer (>10.000 ng/mL), and a positive COVID-19 PCR test. He was diagnosed with a hypercoagulation state in severe COVID-19 and received both supportive and anticoagulant therapy. His condition improved, and he was discharged in good condition after 12 days of hospitalization. Conclusion: In order to get good outcomes, thorough examinations and comprehensive management have to be ensured in patients with a hypercoagulation state due to severe COVID-19.

Comparison of Elva Diagnostic SARS-CoV-2 Saliva Nucleic Acid Test Kit with RT-qPCR and Rapid Antigen Tests in COVID-19 Patients

“…This kit is specifically designed for qualitatively detecting nucleic acid from the nucleocapsid (N) gene of the SARS-CoV-2 virus, relying on observable color changes in saliva specimens collected from individuals suspected of being infected with COVID-19. 18,19 The study involves the analysis of saliva specimens using the Elva Diagnostic SARS-CoV-2 Saliva Nucleic Acid Test kit and nasopharyngeal swabs using RAT. The research encompasses confirmed COVID-19 positive individuals as well as those without a confirmed COVID-19 diagnosis, with the investigations conducted at Dr. Soetomo Regional Public Hospital in Surabaya.…”