Hyperconcentrated platelets stored in additive solution: aspects on productivity and <i>in vitro</i> quality

Ringwald, Juergen; Walz, Susanne; Zimmermann, Robert; Zingsem, J.; Strasser, Erwin; Weisbach, Volker; Eckstein, Reinhold

doi:10.1111/j.1423-0410.2005.00645.x

Cited by 35 publications

(42 citation statements)

References 34 publications

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“…The hyperconcentration may have resulted in platelet damage, and therefore we evaluated the Trima system, which uses a different collection system and hyperconcentration method. 8,12,13 Unfortunately, there were no differences in poststorage platelet viability regardless of the Terumo BCT system that was used (Tables 1 and 3; Figure 1A-B).…”

Section: Discussionmentioning

confidence: 97%

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Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS)

Slichter

Corson

Jones

et al. 2014

Blood

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• Extended apheresis platelet storage is dependent on the collection method, storage in a storage solution, and storage bag composition.• The lifespan of the platelet is not intrinsic to the cell, and platelet viability is better maintained in vitro than in vivo.To evaluate the poststorage viability of apheresis platelets stored for up to 18 days in 80% platelet additive solution (PAS)/20% plasma, 117 healthy subjects donated platelets using the Haemonetics MCS1, COBE Spectra (Spectra), or Trima Accel (Trima) systems. Control platelets from the same subjects were compared with their stored test PAS platelets by radiolabeling their stored and control platelets with either 51 chromium or 111 indium. Trima platelets met Food and Drug Administration poststorage platelet viability criteria for only 7 days vs almost 13 days for Haemonetics platelets; ie, platelet recoveries after these storage times averaged 44 6 3% vs 49 6 3% and survivals were 5.4 6 0.3 vs 4.6 6 0.3 days, respectively. The differences in storage duration are likely related to both the collection system and the storage bag. The Spectra and Trima platelets were hyperconcentrated during collection, and PAS was added, whereas the Haemonetics platelets were elutriated with PAS, which may have resulted in less collection injury. When Spectra and Trima platelets were stored in Haemonetics' bags, poststorage viability was significantly improved. Platelet viability is better maintained in vitro than in vivo, allowing substantial increases in platelet storage times. However, implementation will require resolution of potential bacterial overgrowth during storage. (Blood. 2014;123(2):271-280)

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Section: Discussionmentioning

confidence: 97%

“…12,13 For the Haemonetics studies, the platelets were elutriated with PAS instead of plasma during collection by sterile docking a Haemonetics bag (Effluent #692) containing PAS to the collection set. The operator would unclamp and, as appropriate, clamp the tubing to the #692 bag to permit surging with PAS.…”

Section: Pas Plateletsmentioning

confidence: 99%

Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS)

Slichter

Corson

Jones

et al. 2014

Blood

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“…Es ist möglich, auch ATK plasmareduziert in additiver Lösung herzustellen [64][65][66][67][68][69] [90]. In diesen Studien wurden fast ausschließlich ATK verwendet [83,87,95].…”

Section: Hb-gehalt Der Ekunclassified

Wissenschaftliche Erläuterungen zur Stellungnahme „Bewertung von Apherese- und Pool-Thrombozytenkonzentraten“ des AK Blut vom 31.03.2015

2015

Bundesgesundheitsbl.

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“…Furthermore, the use of platelet additive solution could help to improve storage conditions and thus increase the shelf life of the platelets while maintaining the viability and hemostatic function. [23] The present study was done to assess the in vitro function of random donor platelets stored for 7 days in composol platelet additive solution at 22°C.…”

Section: Introductionmentioning

confidence: 99%

In vitro function of random donor platelets stored for 7 days in composol platelet additive solution

Gupta

Chandra

Kumar

2011

Asian J Transfus Sci

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Background and Aim:Platelets are routinely isolated from whole blood and stored in plasma for 5 days. The present study was done to assess the in vitro function of random donor platelets stored for 7 days in composol platelet additive solution at 22°C.Materials and Methods:The study sample included 30 blood donors of both sex in State Blood Bank, CSM Medical University, Lucknow. Random donor platelets were prepared by platelet rich plasma method. Whole blood (350 ml) was collected in anticoagulant Citrate Phosphate Dextrose Adenine triple blood bags. Random donor platelets were stored for 7 days at 22°C in platelet incubators and agitators, with and without additive solution.Results:Platelet swirling was present in all the units at 22°C on day 7, with no evidence of bacterial contamination. Comparison of the mean values of platelet count, platelet factor 3, lactate dehydrogenase, pH, glucose and platelet aggregation showed no significant difference in additive solution, whereas platelet factor 3, glucose and platelet aggregation showed significant difference (P < 0.001) on day 7 without additive solution at 22°C.Conclusion:Our study infers that platelet viability and aggregation were best maintained within normal levels on day 7of storage in platelet additive solution at 22°C. Thus, we may conclude that in vitro storage of random donor platelets with an extended shelf life of 7 days using platelet additive solution may be advocated to improve the inventory of platelets.

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Hyperconcentrated platelets stored in additive solution: aspects on productivity and in vitro quality

Abstract: TRIMA V4 is a suitable device for the collection of DPs. Nevertheless, improvements are desirable to further increase the ability to concentrate PLTs at very high levels. The storage of apheresis-derived PLTs in PAS III-M is a very promising approach, even at a plasma carryover of < 30%.

Cited by 35 publications

References 34 publications

Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS)

Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS)

Wissenschaftliche Erläuterungen zur Stellungnahme „Bewertung von Apherese- und Pool-Thrombozytenkonzentraten“ des AK Blut vom 31.03.2015

In vitro function of random donor platelets stored for 7 days in composol platelet additive solution

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