Hyperconnectivity of the default mode network in multiorgan dysfunction syndrome

Abstract

Multiple Organ Dysfunction Syndrome (MODS) is a systemic physiological disorder affecting two or more body organs triggered after an insult complication. Beyond the systemic failure, patients who survive MODS present cognitive and neurological impairments that remain stable even several years after Intensive Care Unit (ICU) discharge. Here, we focus on the specific situation of MODS patients with no apparent brain damage (NABD), where the mechanisms driving cognitive impairment at long term are not well-understood. We recruit N 1 = 13 MODS patients with NABD at 6 months after ICU discharge, together with N 2 = 13 healthy controls (matched by age, sex and years