Hypercortisolemia and Infection

Fareau, Gilbert G.; Vassilopoulou‐Sellin, Rena

doi:10.1016/j.idc.2007.06.001

Cited by 64 publications

(65 citation statements)

References 75 publications

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“…Cellular immunity is particularly affected by the hormonal action on neutrophiles, macrophages and lymphocytes Th1, with significant increase on the susceptibility to opportunistic infections, especially the fungal ones. 7,8 The hyperglycemic state found in patients with CD, resulting from the increase of insulin resistance on tissues also contributes to immunosupression. 8 Inflammatory lesions, with little or no symptom and extense distribution on tegument combined with resistance to conventional antifungal treatment are characteristic of lesions caused by dermatophytosis in patients with Cushing's syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The hyperglycemic state found in patients with CD, resulting from the increase of insulin resistance on tissues also contributes to immunosupression. 8 Inflammatory lesions, with little or no symptom and extense distribution on tegument combined with resistance to conventional antifungal treatment are characteristic of lesions caused by dermatophytosis in patients with Cushing's syndrome. Cremer G. was one of the first authors to study the influence of Cushing's syndrome on the development of dermatophytoses.…”

Section: Discussionmentioning

confidence: 99%

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Dermatofitose por Tricophyton rubrum como infecção oportunista em pacientes com doença de Cushing

Peixoto

Maquiné

Francesconi

et al. 2010

An. Bras. Dermatol.

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Abstract:Trichophyton rubrum is a common agent found in superficial mycoses, which present ample nonin?ammatory lesions, with chronic evolution, especially in immunocompromised patients. The hypercortisolism in Cushing's syndrome increases the risk of infections as a result of the immunosuppressive effect of glucocorticoids. The reported cases here refer to two different types of dermatophytosis caused by Trichophyton rubrum in patients with Cushing's disease, resistant to antifungal treatment. The disease remitted after the levels of cortisol went back to normal. Keywords: Cushing's syndrome; Dermatomycoses; Immunosuppression; Onychomycosis Resumo: O dermatófito Trichophyton rubrum é um agente comum nas micoses superficiais, podendo apresentar lesões extensas pauci-inflamatórias de evolução crônica, especialmente em imunocomprometidos. O hipercortisolismo, na síndrome de Cushing, aumenta o risco de infecções, resultado do efeito imunossupressor dos glicocorticóides. Os casos relatados apresentam duas formas distintas de dermatofitose, em pacientes com doença de Cushing, causadas por Tricophyton rubrum e posterior remissão após normalização da cortisolemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dermatofitose por Tricophyton rubrum como infecção oportunista em pacientes com doença de Cushing

Peixoto

Maquiné

Francesconi

et al. 2010

An. Bras. Dermatol.

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“…Aspergillus causes most of the invasive fungal infections in patients treated with glucocorticoids. Pneumocystis jiroveci is well known to cause pneumonia in patients treated with glucocorticoids [8].…”

Section: Hypercortisolemia and Infectionmentioning

confidence: 99%

“…Both Gram-positive bacteria such as Staphylococci, streptococci and listeria, and Gram-negative organisms including enterobacteriacae and Legionella are seen in increased frequency in patients with hypercortisolemia [8].…”

Section: Hypercortisolemia and Infectionmentioning

confidence: 99%

Cushing Syndrome due to Ectopic ACTH Secretion Presenting With Lower Limb Edema and Pulmonary Nocardia Infection: Case Report and Review of the Literature

2016

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Ectopic ACTH secretion has been described since 1962, but its presentation as only lower limbs edema was rarely described. Symptoms and signs are very similar to Cushing disease, but with a more rapid onset and progression of symptoms. Cushing syndrome presenting as lower limbs edema only has been reported once. We present here a case of a 60-year-old male patient with ectopic ACTH secretion presenting with isolated lower limb edema and developing pulmonary nocardia infection.

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“…Invasive nosocomial and systemic fungal infections tare among the main causes of morbidity and mortality, especially in patients with compromised immune systems such as cancer or AIDS, steroid treatments and in organ transplant cases [1][2][3]. Candida species appear to be the main causative agent for nosocomial fungal infections with Candida albicans being the cause of the majority of invasive candidiases with about 30 -40 % of mortality [4].…”

Section: Introductionmentioning

confidence: 99%

Single-Crystal X-ray Structure of Anti-<i>Candida</i> Agent, (E)-3- (1H-Imidazol-1-yl)-1-Phenylpropan-1-one O-3- Chlorobenzoyl Oxime

Attia¹,

Ghabbour²,

Almutairi³

et al. 2015

Trop. J. Pharm Res

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Purpose: To determine the conformation as well as imine double bond configuration of the antiCandida oximino ester, 3-(1H-imidazol-1-yl)-1-phenyl-propan-1-one O-3-chlorobenzoyl oxime. Methods:The titled compound was synthesized in a four-step reaction sequence using acetophenone as a starting material. Spectral analysis, viz, nuclear magnetic resonance (1H NMR and 13C NMR spectroscopy) and mass spectrometry (MS) confirmed the chemical structure of the synthesized compounds. Subsequently, single crystals of the titled compound were subjected to x-ray crystallographic analysis. P21/c with a = 11.1894 (2)Å, b = 19.5577 (4)Å, c = 8.2201 (2)Å, β = 104.919 (2)º, V = 1738.24 (6) Results: The single crystal x-ray crystallography of the investigated anti-Candida agent revealed its conformation and the (E)-configuration of its imine double bond. The titled compound crystallizes in the monoclinic space group

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Hypercortisolemia and Infection

Cited by 64 publications

References 75 publications

Dermatofitose por Tricophyton rubrum como infecção oportunista em pacientes com doença de Cushing

Dermatofitose por Tricophyton rubrum como infecção oportunista em pacientes com doença de Cushing

Cushing Syndrome due to Ectopic ACTH Secretion Presenting With Lower Limb Edema and Pulmonary Nocardia Infection: Case Report and Review of the Literature

Single-Crystal X-ray Structure of Anti-<i>Candida</i> Agent, (E)-3- (1H-Imidazol-1-yl)-1-Phenylpropan-1-one O-3- Chlorobenzoyl Oxime

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