Hyperdynamic Myocardial Response to Beta-Adrenergic Stimulation in Patients With Chest Pain and Normal Coronary Arteries

Maďarič, Juraj; Bartúnek, Jozef; Verhamme, Katia; Pěnička, Martin; Schuerbeeck, Eddy Van; Nellens, Paul; Heyndrickx, Guy R.; Wijns, William; Vanderheyden, Marc; Bruyne, Bernard De

doi:10.1016/j.jacc.2005.06.052

Cited by 21 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10,11 In a study conducted in patients with findings of chest pain and normal coronary arteries, wall motion analysis has shown a LV hypercontractile response to sympathetic stimulation. 12 The same study showed that hypertension was more frequent in patients with hypercontractile response to stress compared with those without hypercontractility. Microneurography and isotope dilution studies of sympathetic activity in hypertensives have shown that increased sympathetic activity and its trophic effects on cardiac muscle are directly related to the development of LVH.…”

Section: Introductionmentioning

confidence: 91%

“…LV hypercontractility in the earlier stage of hypertensive heart disease is detectable at rest and under stress in the outpatient setting. [7][8][9][10][11][12]32,58 Recently, it has been demonstrated by comprehensive imaging studies, that LV contractility parameters are blunted by stress in the HFPEF group. 59,60 These findings have consistently correlated with poor prognostic factors of low EF and larger volume under stress.…”

Section: Sympathetic Stimulation and Dynamics In Hypertension-mediatementioning

confidence: 99%

See 1 more Smart Citation

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Yalçın

Küçukler

et al. 2010

J Hum Hypertens

View full text Add to dashboard Cite

Excessive sympathetic activity and stress-induced left ventricular (LV) hypercontractility have been described in hypertensive LV hypertrophy. Recent quantitative data have shown that hypertensive LV hypertrophy is associated with preserved global LV function. However, progression of uncontrolled hypertension have detrimental effects on both the ejection fraction (EF) and LV contractile response to stress. Hypertensive LV hypertrophy has some common characteristics, including preserved global LV systolic function and LV volume with heart failure with preserved EF (HFPEF), which makes it difficult to differentiate between the two conditions at rest. Studies suggest that adopting an efficient antihypertensive therapy regimen may positively effect on the LV contractile capability in patients with long-standing hypertension. Evaluation of quantitative LV contractility under stress may be beneficial to differentiate between the hypertensive LV hypertrophy and HFPEF. It may also assist in developing a more effective modality in medical management of patients with hypertensive heart disease.

show abstract

Section: Introductionmentioning

confidence: 91%

Section: Sympathetic Stimulation and Dynamics In Hypertension-mediatementioning

confidence: 99%

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Yalçın

Küçukler

et al. 2010

J Hum Hypertens

View full text Add to dashboard Cite

show abstract

“…Although definitive controlled trials are not available, beta blockers seem to be most effective in reducing the frequency and severity of angina and in improving exercise tolerance [63][64][65][66], and they are considered as first line treatment [6,50]. They may also improve exercise tolerance and decrease symptoms [67].…”

Section: Antianginal Therapymentioning

confidence: 99%

Cardiac syndrome X: Current concepts

Singh

Arora

et al. 2010

International Journal of Cardiology

View full text Add to dashboard Cite

“…LV basal cavity volume is diminished due to prominent LV basal myocardium in real-time 3-dimensional imaging and hypercontractile LV base under stress is the usual finding in hypertension (11,12). Stress-mediated exaggerated hypertension, myocardial hypercontractility and LV outflow gradients or increased intracardiac may be detected in hypertensive patients (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Complete reverse remodeling in acute stress cardiomyopathy. Is preserved tissue contractility under stress related to reverse remodeling

Yalçın

Küçukler

et al. 2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Acute stress cardiomyopathy is the unique disease which represents exaggerated and dysfunctional regions of the same cardiac tissue at the same episode. The impressive clinical course which involves the specific region is the stress-mediated exaggerated function of LV base under acutely developed stress induction. After abolishment of stress induction, dysfunctional part of LV which is the midapical myocardium undergoes a complete tissue functional recovery. The evolution of reverse remodeling in acute stress cardiomyopathy has been described using 2 and 3-dimensional echocardiography in the literature. This is the second report regarding reverse LV remodeling in acute stress cardiomyopathy in which we rather evaluate the underlying mechanisms leading complete reverse LV remodeling of dysfunctional myocardium. Therefore, we focus on the existence of preserved and exaggerated regional tissue under stress which possibly represents the predicted myocardial tissue recovery in this acute clinical entity. We also discuss the potential contribution of short-term disease course and lack of prior disease episodes to complete reverse remodeling differently from the heavy burden of chronic diseases leading to permanent tissue jeopardy. (Anadolu Kardiyol Derg 2014; 14: 73-5)

show abstract

Hyperdynamic Myocardial Response to Beta-Adrenergic Stimulation in Patients With Chest Pain and Normal Coronary Arteries

Abstract: The present data suggest that an exaggerated myocardial response to beta-adrenergic stimulation plays a role in the mechanisms of chest pain in some patients with normal coronary arteries.

Cited by 21 publications

References 30 publications

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Cardiac syndrome X: Current concepts

Complete reverse remodeling in acute stress cardiomyopathy. Is preserved tissue contractility under stress related to reverse remodeling

Contact Info

Product

Resources

About