Hyperfibrinogenemia is associated with inflammatory mediators and poor prognosis in patients with gastric cancer

Suzuki, Takashi; Shimada, Hideaki; Nanami, Tatsuki; Oshima, Yoshiteru; Yajima, Satoshi; Ito, Masaaki; Washizawa, Naohiro; Kaneko, Hironori

doi:10.1007/s00595-016-1339-z

Cited by 50 publications

(41 citation statements)

References 17 publications

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“…The independent prognostic value of increased fibrinogen level has been demonstrated in 351 surgically treated gastric cancer patients. The hazard ratio was 2.61 (95% CI = 1.18-5.76) as reported by Suzuki et al [111]. The independent prognostic role was confirmed in another large surgically treated cohort of 1196 gastric cancer patients [112].…”

Section: Fibrinogen In Gastric Cancer Evaluationsupporting

confidence: 62%

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Štrumfa¹,

Bogdanova²,

Kalva³

et al. 2017

Gastric Cancer

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Gastric cancer induces systemic inflammatory reaction (SIR) manifesting with changes in counts of white blood cell fractions and concentrations of acute phase proteins, clotting factors and albumins. Thus, protein-based scores or blood cell ratios (neutrophil to lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR)) are used to evaluate SIR. SIR tests are biologically justified by multiple clinically important and fascinating events including bone marrow activation, development of immune-suppressing immature myeloid cells, generation of pre-metastatic niches and neutrophil extracellular trap formation from externalised DNA network in bidirectional association with platelet activation. Despite biological complexity, clinical SIR assessment is widely available, patient-friendly and economically feasible. Here we present concise review on NLR, PLR, Glasgow prognostic score and fibrinogen -parameters that have prognostic role regarding overall, cancer-free and cancer-specific survival in early and advanced cases. Tumour burden can be predicted helping in preoperative detection of serosal or lymph node involvement. Practical consequences abound, including selection of surgical approach in respect to tumour burden, adjustments in treatment intensity by prognosis or evaluation of chemotherapy response. The chapter also scrutinises main controversies including different cut-off levels. Future developments should include elaboration of complex scores as described here. SIR parameters should be wisely incorporated in patients' treatment.

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Section: Fibrinogen In Gastric Cancer Evaluationsupporting

confidence: 62%

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Štrumfa¹,

Bogdanova²,

Kalva³

et al. 2017

Gastric Cancer

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“…In a cohort of 315 GC patients undergoing surgery, Suzuki et al 111 showed that tumor progression was significantly associated with hyperfibrinogenemia concomitant with inflammation evaluated with protein C-reactive levels, and plasma FBG levels significantly decreased after radical surgery. In this study, hyperfibrinogenemia emerged as an independent prognostic factor for poor survival.…”

mentioning

confidence: 99%

Coagulation and fibrinolysis in gastric cancer

Repetto

2017

Annals of the New York Academy of Sciences

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Coagulation is a highly conserved process occurring after an injury to a blood vessel and resulting in hemostasis. In the thrombus microenvironment, finely orchestrated events restore vessel integrity through platelet activation, adhesion, and aggregation (primary hemostasis), followed by the coagulation cascades, thrombin generation, and fibrin clot deposition (secondary hemostasis). Several studies on cancer have provided insight into dramatic changes to coagulation-related events (i.e., fibrin clot deposition, fibrinolysis) during tumor pathogenesis, progression, and metastasis, in addition to a tumor-driven systemic activation of hemostasis and thrombosis (Trousseau's syndrome). Diverse molecular and cellular effectors participate in the cross talk between hemostasis and tumors. Here, we focus on some aspects of the interconnection between cancer biology and hemostatic components, with particular attention to some key coagulation-related proteins (e.g., tissue factor, thrombin, fibrinogen, and D-dimers) in the particular case of gastric cancer (GC). Recent advances in deciphering the complex molecular link between GC and the coagulation system are described, showing their important roles in better management of patients affected by GC.

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“…The clinical prognosis of advanced gastric cancer is poor; therefore, multimodal treatments before and/or after operation are being developed . The identification of new suitable biomarkers for predicting prognosis is increasingly important to determine whether patients should or should not receive neoadjuvant or adjuvant therapy …”

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confidence: 99%

“…(2)(3)(4) The identification of new suitable biomarkers for predicting prognosis is increasingly important to determine whether patients should or should not receive neoadjuvant or adjuvant therapy. (5,6) In 1977, leucine-rich a2-glycoprotein-1 (LRG1) was the first identified member of the leucine-rich repeat family in human serum. (7) It is an approximately 50-kDa secreted glycoprotein that contains eight repeating consensus sequences with a leucine-rich motif.…”

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confidence: 99%

Overexpression of leucine‐rich α2‐glycoprotein‐1 is a prognostic marker and enhances tumor migration in gastric cancer

et al. 2017

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Gastric cancer is one of the most common malignant tumors. Although improvement in chemotherapy has been achieved, the clinical prognosis of advanced gastric cancer remains poor. Therefore, it is increasingly important to predict the prognosis and determine whether patients should or should not receive neoadjuvant or adjuvant chemotherapy. Leucine‐rich α2‐glycoprotein‐1 (LRG1) is overexpressed during inflammation and is associated with various malignancies. In this study, we assessed LRG1 expression in cancer specimens and in the sera of patients with cancer to clarify the usefulness of LRG1 as a biomarker in gastric cancer. This study enrolled 239 (for immunohistochemical staining; IHC) and 184 (for ELISA) patients with gastric cancer. Results of IHC showed that LRG1 expression was significantly associated with histological type, lymphatic and venous invasion, tumor and node factors, and disease stage. Overall survival was significantly worse in the high LRG1 expression group than in the low LRG1 group (P = 0.0003). Cox multivariate analysis of overall survival revealed that LRG1 expression was an independent prognostic factor (P = 0.0258). Serum LRG1 was significantly higher in gastric cancer patients than in healthy volunteers, and increased as the pathological stage progressed. Furthermore, a significant correlation was revealed between serum LRG1 level and LRG1 expression with IHC (P < 0.0001). Inhibition of LRG1 significantly decreased cell proliferation in vitro (migratory and invasive capacity of gastric cancer cells). These results suggest that LRG1 expression in tumors and serum may be a useful prognostic marker in gastric cancer patients.

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Hyperfibrinogenemia is associated with inflammatory mediators and poor prognosis in patients with gastric cancer

Abstract: Preoperative hyperfibrinogenemia was associated with tumor progression, inflammatory mediators, and poor overall survival in patients with gastric cancer.

Cited by 50 publications

References 17 publications

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Coagulation and fibrinolysis in gastric cancer

Overexpression of leucine‐rich α2‐glycoprotein‐1 is a prognostic marker and enhances tumor migration in gastric cancer

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