Hyperglycemia after Repeated Periocular Dexamethasone Injections in Patients with Diabetes

Corticothérapie et diabète

“…Une corticothérapie locale peut conduire à une hyperglycémie latente : infiltrations à base de GCS à visée rhumatologique (affections rachidiennes, syndrome du canal carpien, maladie de Dupuytren, gonarthrose, capsulite rétractile) [32], infiltrations sous-conjonctivales et péribulbaires pour des affections ophtalmologiques [33]. Toutefois, ce sont les corticothérapies systémiques et en particulier celles sous forme de bolus intraveineux qui sont les principales pourvoyeuses d'un déséquilibre glycémique.…”

Effect of Dexamethasone Eyedrops on Blood Glucose Profile

“…Feldman-Billard et al 20 showed recently that periocular injections with dexamethasone in patients with type 2 diabetes induced a marked hyperglycemic effect. In accordance with these studies, our randomized, controlled study found a change in plasma glucose levels, up to 1 month of follow-up, in the diabetic group only.…”

Ventilator-Induced Lung Injury: Mechanisms and Future Therapeutic Interventions

“…Moreover, liposomes preferably extravasate into tissues with increased capillary permeability (Storm & Crommelin, 1998) facilitating delivery at sites of inflammation and/or mechanical stretch. Previously, Ásgeirsdóttir et al clearly showed that delivery of liposomeencapsulated dexamethasone inhibits pro-inflammatory gene expression without affecting blood glucose levels (Asgeirsdottir et al, 2007), one of the first clinically relevant side effects of free dexamethasone treatment (Feldman-Billard et al, 2006;Weinstein et al, 1995). Because local delivery of glucocorticoids by liposomal formulations could be of therapeutic importance in the context of VILI as well, we studied whether liposomes containing dexamethasone (Dexliposomes) inhibited ventilator-induced lung inflammation (Hegeman et al, 2011a).…”