2012
DOI: 10.2337/db11-1378
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Hyperglycemia and a Common Variant ofGCKRAre Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

Abstract: We investigated the association of glycemia and 43 genetic risk variants for hyperglycemia/type 2 diabetes with amino acid levels in the population-based Metabolic Syndrome in Men (METSIM) Study, including 9,369 nondiabetic or newly diagnosed type 2 diabetic Finnish men. Plasma levels of eight amino acids were measured with proton nuclear magnetic resonance spectroscopy. Increasing fasting and 2-h plasma glucose levels were associated with increasing levels of several amino acids and decreasing levels of histi… Show more

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Cited by 247 publications
(236 citation statements)
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“…These studies showed that elevated levels of branched-chain and aromatic amino acids and lower levels of glycine are associated with incident type 2 diabetes or deteriorating glucose homeostasis [84,[86][87][88][89][90]. In addition, various lipid species and lipid fractions [85,[87][88][89][90], as well as other small metabolites [87,89,91], showed significant associations with the risk of type 2 diabetes or incident impaired glucose metabolism after adjustment for multiple confounders.…”
Section: Lipids and Small Metabolitesmentioning
confidence: 98%
See 1 more Smart Citation
“…These studies showed that elevated levels of branched-chain and aromatic amino acids and lower levels of glycine are associated with incident type 2 diabetes or deteriorating glucose homeostasis [84,[86][87][88][89][90]. In addition, various lipid species and lipid fractions [85,[87][88][89][90], as well as other small metabolites [87,89,91], showed significant associations with the risk of type 2 diabetes or incident impaired glucose metabolism after adjustment for multiple confounders.…”
Section: Lipids and Small Metabolitesmentioning
confidence: 98%
“…Very recently, data on lipids and small metabolites have become available from prospective studies, and these are summarised in Table 2 [84][85][86][87][88][89][90][91]. These studies showed that elevated levels of branched-chain and aromatic amino acids and lower levels of glycine are associated with incident type 2 diabetes or deteriorating glucose homeostasis [84,[86][87][88][89][90].…”
Section: Lipids and Small Metabolitesmentioning
confidence: 99%
“…Even mild hyperglycemia induced these results. The effects were more pronounced in obese than in lean men [37]. As GDM has pathophysiological similarities to T2DM, the metabolite profiles in GDM were considered to be similar to those in T2DM.…”
Section: Resultsmentioning
confidence: 99%
“…Recent metabolomics studies have detected numerous metabolites correlating with insulin resistance and T2DM [11][12][13][14]. Metabolic profiles have been shown to be altered as early as 3-12 years before the diagnosis of T2DM [15][16][17].…”
Section: Introductionmentioning
confidence: 99%
“…High insulin levels were shown to stimulate skeletal muscle protein synthesis [14]. As to individual amino acids, the plasma levels of alanine, phenylalanine, valine, leucine, isoleucine, and tyrosine were shown to increase and the plasma levels of histidine and glutamine were shown to decrease in hyperglycemia [15].…”
Section: Discussionmentioning
confidence: 99%