Hypericin: A natural anthraquinone as promising therapeutic agent

Wu, Jingjing; Zhang, Jia; Xia, Changfa; Ding, Kang; Li, Xinxin; Pan, Xue-Ge; Xu, Jiaming; He, Jun; Zhang, Wei-Ku

doi:10.1016/j.phymed.2023.154654

Cited by 22 publications

(8 citation statements)

References 284 publications

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“…127 Chao et al (2018) developed hypericin-functionalized graphene oxide loaded with Dox, which resulted in enhanced combined anticancer effects of phototherapy and chemotherapy without any observed side effects. 128 This was observed in MD-MB-231 and MCF-7 cells. In addition to that, the functionalized nanoplatform showed low toxicity toward normal cells.…”

Section: Reviewmentioning

confidence: 81%

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Pandya,

Singh,

Desimone

et al. 2024

Mater. Adv.

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Section: Reviewmentioning

confidence: 81%

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Pandya,

Singh,

Desimone

et al. 2024

Mater. Adv.

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“…Therefore, GL could be a promising natural treatment option for MAFLD. Similarly, hypericin, also known as quercetin 3-o-β-d-galactoside, is a bioactive flavonoid glycoside that can be found in Epilobium, Hypericum, and Hypericum (Wu et al, 2023). Numerous studies have demonstrated the wide range of pharmacological activities associated with hypericin, indicating its potential use as a pharmaceutical ingredient (Jiang et al, 2013).…”

Section: Target Macrophagesmentioning

confidence: 99%

Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

Ouyang

Zhu

2023

Front. Pharmacol.

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MAFLD stands for metabolic-related fatty liver disease, which is a prevalent liver disease affecting one-third of adults worldwide, and is strongly associated with obesity, hyperlipidemia, and type 2 diabetes. It encompasses a broad spectrum of conditions ranging from simple liver fat accumulation to advanced stages like chronic inflammation, tissue damage, fibrosis, cirrhosis, and even hepatocellular carcinoma. With limited approved drugs for MAFLD, identifying promising drug targets and developing effective treatment strategies is essential. The liver plays a critical role in regulating human immunity, and enriching innate and adaptive immune cells in the liver can significantly improve the pathological state of MAFLD. In the modern era of drug discovery, there is increasing evidence that traditional Chinese medicine prescriptions, natural products and herb components can effectively treat MAFLD. Our study aims to review the current evidence supporting the potential benefits of such treatments, specifically targeting immune cells that are responsible for the pathogenesis of MAFLD. By providing new insights into the development of traditional drugs for the treatment of MAFLD, our findings may pave the way for more effective and targeted therapeutic approaches.

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“…[17][18][19] Hypericin extracted from Hypericum perforatum L. can not only induce efficient PDT, but also activate strong tumor immune response. [20][21][22] Anthraquinones extracted from rhubarb can be used as chemo-photodynamic therapy agents for cancer treatment. [23] However, most of these natural PS molecules are hydrophobic.…”

Section: Introductionmentioning

confidence: 99%

Molecular Nanoarchitectonics of Natural Photosensitizers and Their Derivatives Nanostructures for Improved Photodynamic Therapy

Li,

Liu,

et al. 2024

ChemMedChem

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Natural photosensitizers (PSs) and their derivatives have drawn ever‐increasing attention in photodynamic therapy (PDT) for their wild range of sources, desirable biocompatibility, and good photosensitivity. Nevertheless, many factors such as poor solubility, high body clearance rate, limited tumor targeting ability, and short excitation wavelengths severely hinder their applications in efficient PDT. In recent years, fabricating nanostructures by utilizing molecular assembly technique is proposed to solve these problems. This technique is easy to put into effect, and the assembled nanostructures could improve the physical properties of the PSs so as to meet the requirement of PDT. In this concept, we focus on the construction of natural PSs and their derivatives nanostructures through molecular assembly technique to enhance PDT efficacy (Figure 1). Furthermore, current challenges and future perspectives of natural PSs and their derivatives for efficient PDT are discussed.

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Hypericin: A natural anthraquinone as promising therapeutic agent

Cited by 22 publications

References 284 publications

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

Molecular Nanoarchitectonics of Natural Photosensitizers and Their Derivatives Nanostructures for Improved Photodynamic Therapy

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