Hypericin Loaded Liposomes for Anti‐Microbial Photodynamic Therapy of Gram‐Positive Bacteria

Plenagl, Nikola; Seitz, Benjamin Sebastian; Pinnapireddy, Shashank Reddy; Jedelská, Jarmila; Brüßler, Jana; Bakowsky, Udo

doi:10.1002/pssa.201700837

Cited by 26 publications

(24 citation statements)

References 33 publications

(36 reference statements)

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“…It was also observed that photodynamic treatment using an invasomes formulation was even more effective than 1% chlorohexidine, a conventional disinfectant, which caused a bacterial reduction of only 1.2 log CFU. A very recent study concerning the limited use of hypericin (HYP, Figure 34 ) as a PS due to its highly lipophilic nature, poor solubility in aqueous media, and poor bioavailability showed that its incorporation in liposomes could be a promising alternative [ 167 ]. The results revealed that the liposomal formulations of DOPE/CHEMS/DPPC (1,2-dioleoyl- sn -glycero-3-phosphoethanolamine/cholesteryl hemisuccinate/ l -α-dipalmitoylphosphatidylcholine), DSPC/DPPC/DSPE-PEG (1,2-distearoyl- sn -glycero-3-phosphatidylcholine/ l -α-dipalmitoylphosphatidylcholine/1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)-2000] and DPPC/DOTAP loaded with HYP were able to attain a 2.3–2.5 log reduction of Staphylococcus saprophyticus subsp.…”

Section: Liposomesmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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Microbial infection is a severe concern, requiring the use of significant amounts of antimicrobials/biocides, not only in the hospital setting, but also in other environments. The increasing use of antimicrobial drugs and the rapid adaptability of microorganisms to these agents, have contributed to a sharp increase of antimicrobial resistance. It is obvious that the development of new strategies to combat planktonic and biofilm-embedded microorganisms is required. Photodynamic inactivation (PDI) is being recognized as an effective method to inactivate a broad spectrum of microorganisms, including those resistant to conventional antimicrobials. In the last few years, the development and biological assessment of new photosensitizers for PDI were accompanied by their immobilization in different supports having in mind the extension of the photodynamic principle to new applications, such as the disinfection of blood, water, and surfaces. In this review, we intended to cover a significant amount of recent work considering a diversity of photosensitizers and supports to achieve an effective photoinactivation. Special attention is devoted to the chemistry behind the preparation of the photomaterials by recurring to extensive examples, illustrating the design strategies. Additionally, we highlighted the biological challenges of each formulation expecting that the compiled information could motivate the development of other effective photoactive materials.

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Section: Liposomesmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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“…10,12‐tridodecadiynoic acid (TCDA) /phospholipid vesicles and TCDA/photosensitizer/phospholipid vesicles were assembled into a matrix with good morphology, and the uniform distribution of the liposome diameter was confirmed by SEM, TEM, and DLS. Compared with TCDA/phospholipid vesicles (136.8 nm), TCDA/photosensitizer/phospholipid vesicles had larger diameters (191.7 nm) because of the loading of photosensitizers, which results in a slight increase in lipid vesicles due to the high deformability of the phospholipid double layer …”

Section: Methodsmentioning

confidence: 99%

“…Compared with TCDA/ phospholipid vesicles (136.8 nm), TCDA/photosensitizer/ phospholipid vesicles had larger diameters (191.7 nm) because of the loading of photosensitizers, which results in a slight increase in lipid vesicles due to the high deformability of the phospholipid double layer. [28] Compared with that of phospholipid vesicles, incorporation of TCDA resulted in a significant increase in temperature, possibly because of the packing effect of the TCDA/lipid bilayer. The phospholipid vesicles feature a liquid crystalline phase at room temperature, leading to the release of payloads if no TCDA structure is applied to the bilayer.…”

mentioning

confidence: 99%

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

et al. 2020

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Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. In this work, trithiophene aldehyde (3T‐CHO) as a new photosensitizers was isolated from Herba Ecliptae, and tryptophan (Trp) modified 3T‐CHO improve water solubility and reduced phototoxicity. The photosensitizer‐loaded vesicles were incorporated into a gel scaffold to obtain a wound dressing with detection and antibacterial function. Detection of the presence of pathogenic bacteria, such as Pseudomonas aeruginosa, based on the fluorescence signals was highly efficient and sensitive. The cytotoxin produced by the pathogenic bacteria to induce vesicle lysis, thereby the photosensitive antibacterial agent was released from the vesicle to realize the simultaneous intelligent detection and treatment of pathogenic bacteria. Compared with traditional dressings coated with antibiotics, the synthesized dressing avoids the drawback of pathogenic bacteria developing drug resistance. The proposed microbiologically responsive wound dressing could be used as a general methodology for the design and fabrication of bacterium‐responsive functional biomaterials.

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“…Liposomal hypericin ( Hyp ) exerts antitumor, antiangiogenic effects [ 76 ] and anti ‐Gram‐positive bacteria activity. [ 77 ] Caeano et al. studied Hyp in DPPC liposomes ( Figure 4 ).…”

Section: Construction Of Liposomal Systems For Pdtmentioning

confidence: 99%

Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

et al. 2021

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Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half‐life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi‐functional nano‐carriers for drug delivery, have been extensively studied in multi‐functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image‐guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome‐based drug delivery.

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Hypericin Loaded Liposomes for Anti‐Microbial Photodynamic Therapy of Gram‐Positive Bacteria

Cited by 26 publications

References 33 publications

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

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