Hyperleptinemia as a risk factor for post-transplant diabetes mellitus development after kidney transplantation

Abstract

INTRODUCTION: Adipose tissue is involved in the synthesis of hormones that have an impact on food intake regulation, control of insulin sensitivity or regulation of infl ammatory processes. The aim of this study was to determine the importance of adipocytokines and interleukins levels for the development of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT). MATERIAL AND METHODS: In the prospective analysis, the studied sample (n = 104) was divided into the control group, prediabetes group and PTDM group. Prior to transplantation, and subsequently, at 3, 6 and 12 months after KT, we recorded the basic characteristics of the donor and recipient, including parameters refl ecting graft function, metabolic and anthropometric parameters. At the same time, we monitored the levels of adiponectin, leptin and interleukins during the monitored period. RESULTS: Using multivariate logistic regression, we identifi ed hyperleptinemia 12 months after KT as an independent risk factor for PTDM development 1 year after KT [OR 1.0320; 95% Cl 0.9785-1.0884 (p=0.0038)]. At the same time, we confi rmed that age at the time of KT is also an independent risk factor for PTDM [OR 1.0903; 95% Cl 1.0149-1.1714 (p = 0.0180)]. CONCLUSION: We confi rmed that elevated leptin level 12 months after KT is associated with the development of PTDM (Tab.

Adiponectin/Leptin Ratio as an Index to Determine Metabolic Risk in Patients after Kidney Transplantation

“…Monitoring adipose tissue hormones in association with cardiometabolic risk factors has only a short history in the transplant population, and until now these hormones have been used as separate variables. In previous studies, we confirmed that hyperleptinemia is an independent risk factor for the development of PTDM, and a low level of adiponectin was associated with insulin resistance and obesity [15].…”