Hyperlipémies dépendantes de l’alcool

Abstract

The authors report a study of 28 cases of hyperlipemia due to alcohol. Clinically, they emphasize the predominance of the male sex, the high incidence of digestive disturbances, weight loss and hepatomegaly and the rarity of cardiovascular involvement. From the biochemical point of view, the majority of cases present an endogenous hyperlipemia of the same type as that induced by carbohydrates. Attention is also drawn to the disturbed glucose balance and the frequent hyperuricemia. Moreover, demonstration of lipid anomalies in the relatives of 11 cases out of 15 suggests a genetic predisposition rather analogous to that in carbohydrate hyperlipemia. Treatment by simple withdrawal of alcohol is always effective, but very unreliably adhered to by these patients.

Hyperlipidemia and pancreatitis

“…We did not find that steatosis was significantly more common in these patients, and diabetes was remarkably uncommon. We observed a tendency, though not significant, for the triglycerides to decrease during the period of acute hospitalization, an observation also made by Gennes et al [8]. Perhaps this tendency explains why some authors have considered the hyperlipidemia to be of a transient nature.…”

“…In our IVFTT the serum triglyceride levels often increase to more than 30 mmol/l, which is much more than should be needed, but possibly this elevation is too transient. Most studies, including ours, have found that the abnormalities in lipid metabolism are constant [5,8,9,14,17]. It has been suggested that hypertriglyceridemia is usually seen in pancreatitis when steatosis of the liver or diabetes is present [5,9,27,28].…”

“…The serum triglyceride levels are supposed to increase above 1000 mg/dl before an attack is provoked. It has been suggested that hypertriglyceridemia is usually seen in pancreatitis when steatosis of the liver or diabetes is present [5,9,27,28]. Most studies, including ours, have found that the abnormalities in lipid metabolism are constant [5,8,9,14,17].…”

“…Alcohol is known to cause an increase in serum triglycerides, although such an increase is often rather transient and especially occurs in patients who already have hyperlipidemia or steatosis [8,27,[29][30][31][32][33][34]. Alcohol is known to cause an increase in serum triglycerides, although such an increase is often rather transient and especially occurs in patients who already have hyperlipidemia or steatosis [8,27,[29][30][31][32][33][34].…”

“…The incidence of 32.5% in our study agrees well with the literature. Patients with hyperlipidemia have been reported to be more prone to develop pancreatitis [7,8,[16][17][18][19]. The forms of hyperlipidemia that have been encountered usually have been types I, IV, and V. The incidence of pancreatitis in patients with type I hyperlipidemia has been over 30%, in patients with type IV around 15%, and in patients with type V 27-41% [7,8].…”