Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1&amp;alpha; upregulation

Zhao, Hu; Wang, Yehong; Wu, Ye; Li, Xiaoyü; Yang, Gang; Ma, Xin; Zhao, Rong‐Rui; Liu, Huirong

doi:10.1093/abbs/gmp063

Cited by 34 publications

(39 citation statements)

References 25 publications

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“…In the fructose-fed hypertriglyceridemic rat heart, cholesterol lowering by fenofibrate restored ischemic preconditioning-mediated cardioprotection (Babbar et al, 2013). However, in one study ischemic postconditioning was still effective in hyperlipidemic rats (Zhao et al, 2009a). The effect of hyperlipidemia on remote conditioning has not yet been reported.…”

Section: B Hypertension Cardiac Hypertrophy and Remodelingmentioning

confidence: 98%

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning

Ferdinándy¹,

Hausenloy²,

Heusch³

et al. 2014

Pharmacol Rev

516

501

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Section: B Hypertension Cardiac Hypertrophy and Remodelingmentioning

confidence: 98%

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning

Ferdinándy¹,

Hausenloy²,

Heusch³

et al. 2014

Pharmacol Rev

516

501

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“…Postconditioning can activate a complex cellular signaling cascade, in which cell membrane receptors could serve as the upstream triggers [40] . Interestingly, few recent studies have shown that HIF-1α upregulation is associated with the postconditioningmediated cardioprotection against ischemia-reperfusion injury in normal and hypercholesterolemic animals [41,42] .…”

Section: Involvement Of Hif-1 In Ischemic Preconditioning and Post Comentioning

confidence: 99%

Hypoxia inducible factor 1 (HIF-1) and cardioprotection

2010

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Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH regulation, cell proliferation and viability. Evidence accumulated during the past 7 years suggests a critical role for HIF-1α in mediating cardioprotection. The purpose of our present article is to provide an updated overview on this important regulator of gene expression in the cellular stress-responsive and adaptive process. We have particularly emphasized the involvement of HIF-1 in the induction of cardioprotective molecules, such as inducible nitric oxide synthase (iNOS), hemeoxygenase 1 (HO-1), and erythropoietin (EPO), which in turn alleviate myocardial damages caused by harmful events such as ischemia-reperfusion injury. Despite these advances, further in-depth studies are needed to elucidate the possible coordination or interaction between HIF-1α and other key transcription factors in regulating protein expression that leads to cardioprotection.

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“…Evaluation of the MI size was performed in the I/R and Olm-I/R groups as previously described (23). The left ventricle was deep frozen at -80˚C.…”

Section: Evaluation Of Aar and Myocardial Infarct (Mi) Sizementioning

confidence: 99%

Protective effect of olmesartan against cardiac ischemia/reperfusion injury in spontaneously hypertensive rats

Lü

Chen

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Olmesartan, as a new angiotensin II receptor blocker, has shown beneficial effects on cardiovascular diseases. Nevertheless, the effect of olmesartan on ischemia/reperfusion (I/R) injury in the hypertensive heart has not been investigated. Therefore, the present study aimed to investigate the effect of olmesartan on I/R injury in spontaneously hypertensive rats (SHRs). Experimental groups were designed with a 2x2 factorial design for olmesartan and I/R effects. In the I/R group, the left anterior descending coronary artery (LAD) was ligated for 40 min followed by a 180-min reperfusion. In the sham group, SHRs underwent the same surgical procedure as the I/R group, with the exception that the suture passed under the LAD without being tightened. In the Olm-I/R group, the SHRs received olmesartan (5 mg/kg) for 4 weeks prior to surgery and other procedures were the same as for the I/R group. In the Olm-sham group, the SHRs received olmesartan (5 mg/kg) for 4 weeks prior to surgery and other procedures were the same as for the sham group. Infarct size was measured for the I/R and Olm-I/R groups. Blood pressure (BP), serum creatine kinase (CK), left ventricular mass index (LVMI), high mobility group box 1 (HMGB1) protein expression levels and hypoxia-inducible factor-1α (HIF-1α) mRNA expression levels were measured for all four groups. Olmesartan significantly reduced BP and LVMI in the olmesartan-treated SHRs compared with those in the SHRs that were not treated with olmesartan. HMGB1 and HIF-1α expression levels were significantly decreased in the Olm-sham and Olm-I/R groups compared with those in the sham and I/R groups, respectively. The proportional increase in HIF-1α expression due to I/R was greater in the olmesartan-treated rats than in the untreated rats. Serum CK levels were significantly reduced in the Olm-I/R group compared with those in the I/R group. In conclusion, olmesartan ameliorates left ventricular hypotrophy and protects the heart against I/R injury in addition to lowing BP in SHRs. The protective effect of olmesartan may be partly due to its antioxidative and anti-inflammatory properties.

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Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1α upregulation

Cited by 34 publications

References 25 publications

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning

Hypoxia inducible factor 1 (HIF-1) and cardioprotection

Protective effect of olmesartan against cardiac ischemia/reperfusion injury in spontaneously hypertensive rats

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