Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model

Wei, Aiwu; Song, Yanli; Ni, Tianming; Xiao, Huidongzi; Wan, Yizhao; Ren, Xiaopeng; Li, Huijuan; Xu, Guangli

doi:10.1016/j.lfs.2020.117735

Cited by 26 publications

(25 citation statements)

References 43 publications

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“…Punicalagin enhances autophagic flux to protect primary human STBs from apoptosis induced by stress conditions [203]. Hyperoside activates autophagy and combats inflammatory response in rat model with decreased IL-1β, IL-8, ICAM-1, VCAM-1 and complement C3, thereby rescues pregnancy losses via downregulating mTOR/S6K and TLR4/MyD88/NF-kB [200]. Studies above offer us insights into treatment of RM targeting autophagy.…”

Section: Potential Therapeutic Methods Targeting Autophagy For Smmentioning

confidence: 99%

“…Studies above offer us insights into treatment of RM targeting autophagy. Rapamycin, a mTOR inhibitor to induce autophagy, could also reverse adverse pregnancy outcomes and elevates LC3 stanning in junctional and labyrinth zones in placentae of rats [200]. It effectively induces autophagy to reduce NK cytotoxicity in trophoblasts [148] and promote DSC autophagy and NK residence in decidua [21].…”

Section: Potential Therapeutic Methods Targeting Autophagy For Smmentioning

confidence: 99%

“…Wei et al have confirmed these results in rat model induced by antiphospholipid antibodies. Elevated p62 and mTOR as well as downregulated Beclin-1 and LC3-II are presented in placentae and the impaired autophagy could be rescued by rapamycin [200]. Except for different ways to evaluate of autophagy, cell types and sampling, various pathogenic mechanisms involved in could still be to blame for the inconsistence.…”

Section: Aberrant Autophagy In Sm Patientsmentioning

confidence: 99%

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Insight of Autophagy in Spontaneous Miscarriage

Qin¹,

Shen²,

Zhou³

et al. 2022

Int. J. Biol. Sci.

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In some cases of spontaneous miscarriage (SM), the exact etiology cannot be determined. Autophagy, which is responsible for cellular survival under stress conditions, has also been implicated in many diseases. Recently, it is also surmised to be correlated with SM. However, the detailed mechanism remains elusive. In fact, there are several essential steps during pregnancy establishment and maintenance: trophoblasts invasion, placentation, decidualization, enrichment and infiltration of decidua immune cells (e.g., natural killer, macrophage and T cells). Accordingly, upstream molecules and downstream effects of autophagy are discussed in these processes, respectively. Of note, autophagy regulates the crosstalk between these cells at the maternal-fetal interface as well. Aberrant autophagy is found in villi, decidual stromal cells, peripheral blood mononuclear cells in SM patients, although the findings are inconsistent among different studies. Furthermore, potential treatments targeting autophagy are included, during which rapamycin and vitamin D are hot-spots in recent literatures. To conclude, a moderately activated autophagy is deeply involved in pregnancy, suggesting that autophagy should be a regulator and promising target for treating SM.

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Section: Potential Therapeutic Methods Targeting Autophagy For Smmentioning

confidence: 99%

Section: Potential Therapeutic Methods Targeting Autophagy For Smmentioning

confidence: 99%

Section: Aberrant Autophagy In Sm Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Insight of Autophagy in Spontaneous Miscarriage

Qin¹,

Shen²,

Zhou³

et al. 2022

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

“…Moreover, a recent study using a rat model of immune-mediated pregnancy loss proposed drug-induced placental autophagy as a good candidate for therapy due to the resulting improvement in pregnancy outcomes. Following placental autophagy induction, associated with downregulated mTOR placental expression, the study reported an increased fetal weight and decreased resorption rate due to suppression of placental inflammation ( 136 ).…”

Section: Signs Of Autophagy In Placental and Trophoblast Cells Subjected To Adverse Conditionsmentioning

confidence: 99%

Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview

Toschi

Baratta

2021

Front. Vet. Sci.

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Correct placental development during early gestation is considered the main determinant of fetal growth in late pregnancy. A reduction in maternal nourishment occurring across the early developmental window has been linked to a wide range of pregnancy disorders affecting placental transport capacity and consequently the fetal nutrient supply line, with long-term implications for offspring health and productivity. In livestock, ruminant species specifically experience maternal undernutrition in extensive systems due to seasonal changes in food availability, with significant economic losses for the farmer in some situations. In this review, we aim to discuss the effects of reduced maternal nutrition during early pregnancy on placental development with a specific focus on ruminant placenta physiology. Different types of placental adaptation strategies were examined, also considering the potential effects on the epigenetic landscape, which is known to undergo extensive reprogramming during early mammalian development. We also discussed the involvement of autophagy as a cellular degradation mechanism that may play a key role in the placental response to nutrient deficiency mediated by mammalian target of rapamycin, named the mTOR intracellular pathway.

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“…Traditional Chinese medicine (TCM) refers to the herbs and formulae which is made based on the Five Elements theory, including Metal, Wood, Water, Fire and Earth. Up to now, TCM has been applied for few thousand years in China and other Southeast Asian countries to prevent or cure almost all types of diseases, including the inflammation-related diseases (17)(18)(19). Huanglian-Jie-Du-Tang, a decoction made up of heat-clearing and detoxifying TCM-relevant herbs such as Coptis chinensis, Cortex Phellodendri, Scutellaria baicalensis and Fructus gardenia has been identified to inhibit inflammation in inflamed rats, accompanied with decreased levels of macrophage inflammatory protein-2 (MIP-2), TNF-α, IL-6, IL-1β and IL-10 (20).…”

Section: Introductionmentioning

confidence: 99%

Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation

et al. 2020

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Traditional Chinese medicine (TCM), such as Huanglian-Jie-Du-Tang, a heat-clearing and detoxifying decoction is beneficial for alleviation of inflammation-related diseases. The objective of the present study is to uncover the effect and mechanism of heat-clearing, detoxifying and blood stasis removing decoction (HDBD) on the treatment of acute soft tissue injury (STI) which is characterized with excessive inflammatory cascade at the onset. Male Sprague–Dawley (SD) rats with hammer beating served as the in vivo models of acute STI. Hematoxylin–Eosin (HE) staining was used for histopathology assessment. The levels of inflammatory factors, including prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), interleukin (IL)-1t and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Human dermal microvascular endothelium cell line HMEC-1 and rat vascular endothelium cell line RAOEC were used to explore the mechanism in vitro. Luciferase gene reporter assay was applied to determine the relationship between miR-26b-5p and Cyclo-oxygenase 2 (COX2). The results showed that HDBD intervention significantly reduced the temperature difference between the healthy side and affected side of rats with hammer beating, together with the decreased levels of COX2, PGE2, TNF-α, IL-6 and IL-1β, and the increased level of miR-26b-5p. In mechanism, miR-26b-5p targeted COX2 and decreased its expression, leading to significant decreases in the levels of PGE2, TNF-α and IL-6 in RAOEC and HMEC-1 cells. In addition, miR-26b-5p inhibition impaired the effects of HDBD on the suppression of PGE2, TNF-α, IL-6 and IL-1β in vitro. In conclusion, the present study revealed that HDBD relieved acute STI via modulating miR-26b-5p/COX2 axis to inhibit inflammation.

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Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model

Cited by 26 publications

References 43 publications

Insight of Autophagy in Spontaneous Miscarriage

Insight of Autophagy in Spontaneous Miscarriage

Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview

Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation

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