Hyperparathyroidism in dentistry: Issues and challenges!!

Khalekar, Yogita; Zope, Amit; Brahmankar, Ujwala; Chaudhari, Lalit

doi:10.4103/2230-8210.183452

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…However, high serum levels of Ca 2+ (≥1.51 mmol/L) are associated with an increased probability of tooth extractions (56). Loosening and drifting of teeth due to widened periodontal ligament spaces and partial loss of lamina dura may be misdiagnosed as periodontitis (28). Other intraoral manifestations of hyperparathyroidism include pulp calcifications, dental sensitivity to percussion and mastication, soft tissue calcifications, mandibular tori, and jawbone pain (28,29).…”

Section: Disorders Of Bone Metabolismmentioning

confidence: 99%

“…Loosening and drifting of teeth due to widened periodontal ligament spaces and partial loss of lamina dura may be misdiagnosed as periodontitis (28). Other intraoral manifestations of hyperparathyroidism include pulp calcifications, dental sensitivity to percussion and mastication, soft tissue calcifications, mandibular tori, and jawbone pain (28,29). Primary hyperparathyroidism is associated with pathogenic variants in a range of genes.…”

Section: Disorders Of Bone Metabolismmentioning

confidence: 99%

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Rare Genetic Disorders Affecting the Periodontal Supporting Tissues in Adolescence

et al. 2021

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In adolescents periodontal destruction may be the primary manifestation of an as yet unrecognized rare systemic disease, and it may be up to the periodontist to make the correct tentative diagnosis. Many genetic diseases that present with primary periodontal manifestations in adolescence affect immune function, sometimes with only mild or absent systemic features. They include periodontal Ehlers-Danlos syndrome (lack of attached gingiva, various connective tissue abnormalities), Papillon-Lefèvre syndrome (palmoplantar hyperkeratosis), and plasminogen deficiency (fibrin deposition within mucous membranes). Other immune disorders with severe periodontitis manifesting in adolescence are usually diagnosed in early childhood due to unmistakeable systemic features. They include Cohen syndrome (developmental disorder, truncal obesity, and microcephaly), Hermansky-Pudlak Syndrome (oculocutaneous albinism, bleeding diathesis, and other systemic manifestations), glycogen storage disease type 1b, and Chediak-Higashi syndrome (pyogenic infections, albinism, and neuropathy). The structural integrity of periodontal tissue is affected in genodermatoses such as Kindler syndrome, a type of epidermolysis bullosa. In primary hyperoxaluria, inflammatory periodontal destruction is associated with renal calculi. Breakdown of periodontal tissues independent of dental plaque biofilm-induced periodontitis is found in hypophosphatasia (highly variable skeletal hypomineralization) or isolated odontohypophosphatasia, hypophosphatemic rickets and primary hyperparathyroidism. Finally, alveolar osteolysis mimicking localized periodontitis may be due to neoplastic processes, e.g., in neurofibromatosis type 1 (typical skin features including café au lait macules and neurofibromas), Langerhans cell histiocytosis (locally destructive proliferation of bone marrow-derived immature myeloid dendritic cells), and Gorham-Stout disease (diffuse cystic angiomatosis of bone).

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Section: Disorders Of Bone Metabolismmentioning

confidence: 99%

Section: Disorders Of Bone Metabolismmentioning

confidence: 99%

Rare Genetic Disorders Affecting the Periodontal Supporting Tissues in Adolescence

et al. 2021

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“…disorders include either hyperparathyroidism (increase of PTH secretion) or hypoparathyroidism (decrease of PTH secretion). They can induce various oral and/or extra-oral manifestations [5], accordingly, the dental practitioner must be aware of these findings to be able to correctly diagnose and treat the patient.…”

Section: Parathyroidmentioning

confidence: 99%

“…Primary hyperparathyroidism is usually caused by an adenoma of the gland (85% of cases) leading to a PTH hypersecretion and consequently to hypercalcemia and hypophosphatemia [4,5]. This condition is normally asymptomatic but it can result in bone disease, renal calculi, or neuromuscular symptoms [8].…”

Section: Hyperparathyroidismmentioning

confidence: 99%

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Patients with Parathyroid Disorders: Oral Manifestations and Dental Management

Aoun

Hamdan

Aoun

2021

JAMPS

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Parathyroid hormone secreted by the parathyroid glands has a key role in the regulation of calcium and phosphorus metabolism and plays an essential role in tooth and bone mineralization. Disorders of the parathyroid glands most frequently result in abnormalities of serum calcium and can induce various oral and extra-oral manifestations. Therefore, a sound understanding of these conditions is essential for the dental practitioner, with emphasis on alerting signs, clinical and radiological findings and mandatory communication with patient’s physician.

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