Hyperplastic Polyposis and the Risk of Colorectal Cancer

Abstract

Patients with hyperplastic polyposis are at high risk for colorectal cancer. Failure to identify this subset of patients could have dire consequences.

Phenotypic characterization and familial risk in hyperplastic polyposis syndrome

“…Fifth and sixth decades are the usual age of diagnosis of HPS diagnosis [4,6,17,22]. However, similar to the findings of Chow et al [3], the age of diagnosis in our IC was lower.…”

“…Patients typically have multiple and large hyperplastic polyps (HPs) proximal to the sigmoid colon [2,3] . Different types of serrated polyps as HPs, sessile serrated adenomas (SSAs), traditional serrated adenomas (TSAs) and mixed polyps (MPs) are associated with HPS [3][4][5][6][7] . The SSAs, TSAs and MPs are considered advanced lesions [5,8].…”

“…An increased cancer risk in patients with multiple serrated polyps was reported [2,10,11] especially if they are large, atypical, dysplastic or located proximally [4,7,10,11]. Carcinogenesis in serrated pathway involves a CpG island methylator phenotype (CIMP) and mutation of oncogene BRAF [8,10,11].…”

Polipose hiperplásica: relato de caso

“…A idade média de polipose hiperplásica situase entre 54 a 60 anos de idade [2,4,9]. O paciente do relato apresentou a doença em uma idade incomum, já …”

“…que na maioria dos casos, são acometidos pacientes a partir da terceira década de vida [2,4,9]. Apesar disso, já foram relatados casos de polipose hiperplásica até mesmo em crianças [10].…”