Hyperpolarisation‐activated inward current in isolated sheep mesenteric lymphatic smooth muscle

McCloskey, Karen; Toland, H. M.; Hollywood, Mark A.; Thornbury, Keith D.; McHale, Noel G.

doi:10.1111/j.1469-7793.1999.00201.x

Cited by 64 publications

(71 citation statements)

References 36 publications

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“…In addition, I h was also found in some other tissues such as B cells of pancreatic Langerhans islets (134), enteric (37,179,429), lymphatic smooth muscle (254), uterine smooth muscle (296), smooth muscle cells of the bladder (163) or portal vein (164), testis (341), and the enteric nervous system (427). However, HCN channel transcripts have only been reported in some of these tissues or cell types (134,164,341,427).…”

Section: Tissue Expression Of Hcn Channelsmentioning

confidence: 99%

Hyperpolarization-Activated Cation Channels: From Genes to Function

Biel

Wahl‐Schott²,

Michalakis³

et al. 2009

Physiological Reviews

887

974

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in heart and nervous system. The current produced by HCN channels has been known as Ih (or If or Iq). Ih has also been designated as pacemaker current, because it plays a key role in controlling rhythmic activity of cardiac pacemaker cells and spontaneously firing neurons. Extensive studies over the last decade have provided convincing evidence that Ih is also involved in a number of basic physiological processes that are not directly associated with rhythmicity. Examples for these non-pacemaking functions of Ih are the determination of the resting membrane potential, dendritic integration, synaptic transmission, and learning. In this review we summarize recent insights into the structure, function, and cellular regulation of HCN channels. We also discuss in detail the different aspects of HCN channel physiology in the heart and nervous system. To this end, evidence on the role of individual HCN channel types arising from the analysis of HCN knockout mouse models is discussed. Finally, we provide an overview of the impact of HCN channels on the pathogenesis of several diseases and discuss recent attempts to establish HCN channels as drug targets.

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Section: Tissue Expression Of Hcn Channelsmentioning

confidence: 99%

Hyperpolarization-Activated Cation Channels: From Genes to Function

Biel

Wahl‐Schott²,

Michalakis³

et al. 2009

Physiological Reviews

887

974

View full text Add to dashboard Cite

show abstract

“…A more likely explanation for the lack of spontaneous activity in our experiments is that lymphatic smooth muscle consists of a heterogeneous population of cells. A recent study on isolated sheep mesenteric lymphatic cells has demonstrated the presence of a hyperpolarization-activated inward current in only 5% of cells, suggesting that such heterogeneity does exist between cells in this tissue (24). It is therefore possible that a minority of cells differ in some way to the bulk of the smooth muscle cells and are capable of firing spontaneous action potentials.…”

Section: Replacement Of External CLmentioning

confidence: 99%

“…To date, a variety of potential depolarizing currents have been demonstrated in sheep lymphatic smooth muscle (20,21,24). We have previously shown that blockade of either the T-type Ca 2ϩ current (7) or hyperpolarization-activated inward current (24) slows spontaneous contractions, suggesting that these currents contribute to pacemaking in sheep lymphatics.…”

Section: Replacement Of External CLmentioning

confidence: 99%

Ca²⁺-activated Cl⁻ current in sheep lymphatic smooth muscle

Toland

McCloskey

Thornbury

et al. 2000

American Journal of Physiology-Cell Physiology

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“…Several depolarizing currents have been identified, and their attenuation reduces the rate of spontaneous contractions: these include T-type Ca 2+ current [69,70], Ca 2+ -activated Cl -current [71] and a hyperpolarizing-activated inward current [72]. However, the relative contribution of each component, and whether there are regional or species differences, has not been systematically investigated.…”

Section: Lymphaticsmentioning

confidence: 99%