Hyperpolarized 13C tracers: Technical advancements and perspectives for clinical applications

Fiedorowicz, Michał; Wieteska, Michał; Rylewicz, Katarzyna; Kossowski, Bartosz; Piątkowska-Janko, Ewa; Czarnecka, Anna; Toczyłowska, Beata; Bogorodzki, Piotr

doi:10.1016/j.bbe.2021.03.010

Cited by 4 publications

(2 citation statements)

References 140 publications

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“…The hyperpolarized MR imaging (HP MRI) is an innovative imaging technique of nuclear spin polarization that gives information about metabolic processes in particular tissues (including tumors) in vivo in real-time with using unique injected substrates, usually 1- 13 C pyruvate, which participates in different metabolic pathways and converts into isotope-labeled products [222,223]. Apart from 13 C, the other nuclei may also be hyperpolarized and serve as markers of different molecules, e.g., 1 H, 29 Si, 15 N, 89 Yi, 129 Xe, 31 P [224][225][226].…”

Section: Hyperpolarized Mrimentioning

confidence: 99%

New Perspectives in Imaging of Uveal Melanoma

Solnik¹,

Paduszynska²,

Czarnecka³

et al. 2021

Preprint

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Uveal melanoma is the most common primary intraocular malignancy in adults characterized by insidious onset and poor prognosis strongly associated with tumor size and the presence of distant metastases, most commonly in the liver. Contrary to most tumor identification, biopsy followed by pathological exam is not recommended in ophthalmic oncology. Therefore, early and non-invasive diagnosis is essential to enhance patients’ chances for early treatment possibilities. We reviewed imaging modalities currently used in the diagnosis of uveal melanoma, i.e., fundus imaging, ultrasonography (US), optical coherence tomography (OCT), single-photon emission computed tomography (SPECT), positron emission tomography/computed tomography (PET/CT), magnetic resonance imaging (MRI), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), fundus autofluorescence (FAF). The principle of imaging techniques was briefly explained, along with their role in the diagnostic process and a summary of their advantages and limitations. Further, the experimental data and the advancements in imaging modalities were searched. We described their innovations, showed current usage and research, and explained the possibilities of utilizing them to diagnose uveal melanoma and their potential application in personalized medicine such as theranostics.

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Section: Hyperpolarized Mrimentioning

confidence: 99%

New Perspectives in Imaging of Uveal Melanoma

Solnik¹,

Paduszynska²,

Czarnecka³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“… 16 This phenomenon has been widely used in hyperpolarized magnetic resonance for cancer diagnosis. 17 As the terminal product of glycolysis, pyruvate can readily diffuse into cancer cells and convert into lactate via Lactate dehydrogenase (LDH), alanine via alanine transaminase (ALT) or to metabolites involved in the tricarboxylic acid (TCA) cycle in mitochondria. The carbonyl carbon of [1- 13 C]pyruvate is polarized by PHIP-SAH and purified using our Maximizing Insensitive Nuclei Enhancement Reached Via para-hydrogen Amplification (MINERVA) protocol.…”

mentioning

confidence: 99%