Hyperprolactinaemia and hyperserotoninaemia: their relationship to seminal quality

Gonzales, G. F.; García-Hjarles, Marco Antonio; Velásquez, Guzmán

doi:10.1111/j.1439-0272.1992.tb02617.x

Cited by 30 publications

(24 citation statements)

References 19 publications

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“…Daily injections of 5-HT precursor (5-hydroxytryptophan (5-HTP)) alter reproductive development and age-dependent body weight gain in mice, accompanied by a low testosterone level and highly reduced sperm counts, motility, and viability (Sethi & Chaturvedi 2009). In addition, studies in humans reported that hyperserotonemia derives in azoospermia (Gonzales et al 1989(Gonzales et al , 1992. Furthermore, in reproductive pathologies such as varicocele, 5-HT blood levels are elevated and it has also been proven that serotoninergic neurotransmission dysfunctions are involved in premature ejaculation (de Jong et al 2006, Chan et al 2008, Motofei 2008.…”

Section: Introductionmentioning

confidence: 99%

Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility

Jiménez-Trejo¹,

Tapia-Rodríguez²,

Cerbón³

et al. 2012

Reproduction

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Serotonin (5-hydroxytryptamine; C 10 H 12 N 2 O (5-HT)) is produced in the CNS and in some cells of peripheral tissues. In the mammalian male reproductive system, both 5-HT and tryptophan hydroxylase (TPH) have been described in Leydig cells of the testis and in principal cells of the caput epididymis. In capacitated hamster sperm, it has been shown that 5-HT promotes the acrosomal reaction. The aim of this work was to explore the existence of components of the serotoninergic system and their relevance in human sperm physiology. We used both immunocytochemistry and western blot to detect serotoninergic markers such as 5-HT, TPH1, MAO A , 5-HT 1B , 5-HT 3 , and 5HT T ; HPLC for TPH enzymatic activity; Computer Assisted Semen Analysis assays to measure sperm motility parameters and pharmacological approaches to show the effect of 5-HT in sperm motility and tyrosine phosphorylation was assessed by western blot. We found the presence of serotoninergic markers (5-HT, TPH1, MAO A , 5-HT 1B , 5-HT 2A , 5-HT 3 , 5-HT T , and TPH enzymatic activity) in human sperm. In addition, we observed a significant increase in tyrosine phosphorylation and changes in sperm motility after 5-HT treatment. In conclusion, our data demonstrate the existence of components of a serotoninergic system in human sperm and support the notion for a functional role of 5-HT in mammalian sperm physiology, which can be modulated pharmacologically.

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Section: Introductionmentioning

confidence: 99%

Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility

Jiménez-Trejo¹,

Tapia-Rodríguez²,

Cerbón³

et al. 2012

Reproduction

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“…In the male reproductive system, serotonin might affect directly sperm maturation since the existence of a local serotonergic system in the rat caput epididymis have been described [10]. However, relatively recent studies have reported that hyperserotoninaemia may relate to certain kinds of male infertility [11,12]. In this regard, several studies have pointed out that selective serotonin reuptake inhibitors, which are commonly prescribed as antidepressants, can impair semen quality and damage sperm DNA integrity [13,14].…”

Section: Introductionmentioning

confidence: 99%

The correlation between urinary 5-hydroxyindoleacetic acid and sperm quality in infertile men and rotating shift workers

Ortiz¹,

Espino

Bejarano

et al. 2010

Reprod Biol Endocrinol

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BackgroundSerotonin is a neurotransmitter that modulates a wide range of neuroendocrine functions. However, excessive circulating serotonin levels may induce harmful effects in the male reproductive system. The objective of this study was to evaluate whether the levels of urinary 5-hydroxyindoleacetic acid (5-HIIA), a major serotonin metabolite, correlate with different classical seminal parameters.MethodsHuman ejaculates were obtained from 40 men attending infertility counselling and rotating shift workers by masturbation after 4-5 days of abstinence. Urinary 5- HIIA concentration was quantified by using a commercial ELISA kit. Forward motility was assessed by a computer-aided semen analysis (CASA) system. Sperm concentration was determined using the haemocytometer method. Sperm morphology was evaluated after Diff-Quik staining, while sperm vitality was estimated after Eosin-Nigrosin vital staining.ResultsOur results show that urinary 5-HIIA levels obtained from a set of 20 volunteers negatively correlated with sperm concentration, forward motility, morphology normal range and sperm vitality. On the other hand, we checked the relationship between male infertility and urinary 5-HIIA levels in 20 night shift workers. Thus, urinary 5-HIIA levels obtained from 10 recently-proven fathers were significantly lower than those found in 10 infertile males. Additionally, samples from recent fathers exhibited higher sperm concentration, as well as better forward motility and normal morphology rate.ConclusionsIn the light of our findings, we concluded that high serotonin levels, indirectly measured as urinary 5-HIIA levels, appear to play a role as an infertility determinant in male subjects.

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“…5-HT affects testicular blood flow, testicular development, cAMP and testosterone production (Frungieri et al, 1999). In addition, it was reported in human studies that hyper-serotonemia was associated with decreased sperm count and motility (Gonzales, García-Hjarles, & Velasquez, 1992).…”

Section: Discussionmentioning

confidence: 99%

Kisspeptin and RF9 prevent paroxetine‐induced changes in some parameters of seminal vesicle fluid in the male rats

et al. 2020

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The aim of the study was to examine possible impacts of paroxetine and agomelatine on the levels of some components that constitute the seminal vesicle fluid. As a second purpose, it was also aimed to examine how possible negative effects induced by paroxetine on seminal vesicle fluid components were affected by kisspeptin and RF9 (an RFamide‐related peptide antagonist, RFRP). Forty‐two male rats, aged 21 days, divided into six groups; control, sham, paroxetine, agomelatine, paroxetine + kisspeptin and paroxetine + RF9. Paroxetine (3.6 mg/kg) and agomelatine (10 mg/kg) were administrated by oral gavage. Kisspeptin (1 nmol) and RF9 (20 nmol) were administered intracerebroventricular (i.c.v). The experiments were ended on post‐natal 120 days; fructose, vitamin E, sodium, potassium and magnesium levels were measured in seminal vesicle fluid. Fructose, vitamin E, magnesium and potassium levels were significantly decreased in seminal vesicle fluid from the rats treated with paroxetine but did not show significant differences following agomelatine administration. The co‐administration of kisspeptin or RF9 with paroxetine prevented the paroxetine‐induced negative effects on seminal vesicle fluid components. These results suggest that reduction in sperm fertilising ability caused by changes in seminal vesicle fluid can be seen in long‐term antidepressant use. RF‐9 and kisspeptin might have positive effects on long‐term antidepressant use‐induced infertility.

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Hyperprolactinaemia and hyperserotoninaemia: their relationship to seminal quality

Cited by 30 publications

References 19 publications

Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility

Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility

The correlation between urinary 5-hydroxyindoleacetic acid and sperm quality in infertile men and rotating shift workers

Kisspeptin and RF9 prevent paroxetine‐induced changes in some parameters of seminal vesicle fluid in the male rats

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