Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl  in girls with central precocious puberty

Kauschansky, Arieh; Nussinovitch, Moshe; Frydman, Moshe; Yeshaya, Arie; Ben‐Rafael, Zion

doi:10.1016/s0015-0282(16)57724-3

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Interestingly, reduction of testosterone and estradiol levels with depot gonadotropin-releasing hormone analogues has been reported in some patients when used for treatment of prostate cancer in men [117,118] and precocious puberty in children [119,120].…”

Section: Estrogensmentioning

confidence: 99%

Drugs and prolactin

Molitch

2008

Pituitary

143

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Medications commonly cause hyperprolactinemia and their use must be differentiated from pathologic causes. The most common medications to cause hyperprolactinemia are the antipsychotic agents, although some of the newer atypical antipsychotics do not do so. Other medications causing hyperprolactinemia include antidepressants, antihypertensive agents, and drugs which increase bowel motility. Often, the medication-induced hyperprolactinemia is symptomatic, causing galactorrhea, menstrual disturbance, and erectile dysfunction. In the individual patient, it is important differentiate hyperprolactinemia due to a medication from a structural lesion in the hypothalamic-pituitary area. This can be done by stopping the medication temporarily to determine if the prolactin (PRL) levels return to normal, switching to another medication in the same class which does not cause hyperprolactinemia (in consultation with the patient's physician and/or psychiatrist), or by performing an MRI or CT scan. If the hyperprolactinemia is symptomatic, management strategies include switching to an alternative medication which does not cause hyperprolactinemia, using estrogen/testosterone replacement, or cautiously adding a dopamine agonist.

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