Hyperprolactinemic Anovulatory Syndrome

Bohnet, H. G.; Dahlén, H. G.; Schneider, H. P. G.

doi:10.1530/acta.0.080s026

Cited by 31 publications

(39 citation statements)

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“…According to this study, the increase which was observed in prolactin may be the cause of the low oestrogen and progesterone concentrations in the infertile subjects, which showed that higher serum prolactin concentrations resulted in decreased serum LH and FSH levels in infertile women. This study also showed that there were lower concentrations of serum FSH and LH and higher concentrations of PRL in primary infertile women than in the control group [15][16].…”

supporting

confidence: 64%

Hyperprolactinaemia and its Comparision with Hypothyroidism in Primary Infertile Women

Turankar¹

2013

JCDR

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Aim and Objective: To study the serum prolactin levels and the serum TSH in primary infertile females. Material and Method:In this study, we investigated thirty women who were diagnosed cases of primary infertility, who attended the Biochemistry Department, Sir JJ Group of Hospitals, Mumbai, India, for hormonal evaluations. Thirty fertile women with similar ages were enrolled as the controls. The status of the thyroid dysfunction and the levels of serum prolactin were reviewed in infertile women and in the controls. The serum Prolactin and the thyroid stimulating hormone levels were measured by using Siemens kits in IMMULITE 1000 chemiluminescence immunoassays.Results: In our study, the serum prolactin levels in the infertile group were found to be high as compared to those in the control group and they were highly significant (p<0.0001). The serum TSH levels in the infertile group were found to be high, as compared to those of control group and they were highly significant (p<0.0001).

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supporting

confidence: 64%

Hyperprolactinaemia and its Comparision with Hypothyroidism in Primary Infertile Women

Turankar¹

2013

JCDR

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“…In addition, several older studies on animals demonstrated that normal serum PRL levels are required for a normal testicular function and growth of accessory sex organs, since PRL acts synergistically with LH and testosterone (24,25) and it regulates the levels of the testosterone precursors for conversion under the in¯uence of LH (25). On the other hand, hyperprolactinemia suppressed LH pulse frequency in castrated male rats (26) and decreased testosterone levels by inhibiting gonadotropin-releasing hormone and, consequently, gonadotropin secretion in men (27). Thus, hyperprolactinemia affects male gonadal function, acting at different levels.…”

Section: Discussionmentioning

confidence: 99%

Cabergoline treatment rapidly improves gonadal function in hyperprolactinemic males: a comparison with bromocriptine

Rosa

Colao

Sarno

et al. 1998

European Journal of Endocrinology

120

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This study evaluated the effects of chronic treatment with cabergoline (CAB), a new, potent and longlasting ergoline-derived dopamine agonist, on seminal¯uid parameters and sexual and gonadal function in hyperprolactinemic males in comparison with the effect of bromocriptine (BRC) treatment.Seventeen males with macroprolactinoma were treated with CAB at a dose of 0.5±1.5 mg/week (n 7), or BRC at a dose of 5±15 mg/day (n 10) for 6 months. Baseline prolactin (PRL) was 925.7 6 522.6 mg/l in the CAB-treated group and 1059.4 6 297.6 mg/l in the BRC-treated group. All the patients suffered from libido impairment, ten from reduced sexual potency, and six had infertility. In ®ve patients provocative bilateral galactorrhea was found.Seminal¯uid analysis, functional seminal tests and penis rigidity and tumescence, measured by nocturnal penile tumescence (NPT) using Rigiscan equipment, were assessed before and after 1, 3 and 6 months of CAB or BRC treatment. Hormone pro®les were assessed before and after 15, 30, 60, 90 and 180 days of both treatments.Before treatment, all patients had a low sperm count with oligoasthenospermia, reduced motility and rapid progression with an abnormal morphology and decreased viability, and a low number of erections. After 1 month, serum PRL levels were signi®cantly reduced in both groups of patients (20.6 6 6.6 mg/l during CAB and 256.3 6 115

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“…Normal LH pulsatility can be restored with bromocriptine treatment, resulting in PRL normalization (6)(7)(8)21). Since it has been suggested that bromocriptine can directly affect LH release (22), it is not possible to assert with certainty that the restoration of LH pulsatility is exclusively due to PRL normalization.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, hyperprolactinemia is associated with a reduction in frequency or absence of LH pulses (5)(6)(7)(8). Normalization of PRL with bromocriptine is followed by restoration of LH pulsatility (5)(6)(7)(8), but this action may be due to a central action of bromocriptine rather than a consequence of reduced PRL secretion.…”

mentioning

confidence: 99%

Early Normalization of Luteinizing Hormone Pulsatility after Successful Transsphenoidal Surgery in Women with Microprolactinomas

Stevenaert¹,

Beckers²,

Vandalem³

et al. 1986

The Journal of Clinical Endocrinology & Metabolism

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ABSTRACT. In eight hyperprolactinemic amenorrheic women who had a microprolactinoma, LH secretion was examined by measuring its concentration in blood samples collected every 15 min for 6 h before and 8 days after successful selective adenomectomy. Computer analysis was used for LH peak evaluation. In both circumstances, serum PRL and basal estradiol (E 2 ) levels were also determined. Before operation, the number of LH peaks ranged from zero to one per 6 h in seven patients and was two per 6 h in the eighth patient. In all patients, serum PRL was normal on the eighth postoperative day, while E 2 levels remained low, similar to the values usually found in the early follicular phase of the cycle in normal women. Postoperatively, mean LH levels were similar to preoperative levels, but there was a dramatic increase in the number of LH peaks (three to five per 6 h) in five of the eight patients.These observations confirm the impairment of LH pulsatility in hyperprolactinemia and demonstrate that normalization of PRL levels by surgery can restore LH pulsatile secretion in certain women as early as the eighth day after operation in the absence of a significant change in serum E 2 levels. Thus, the preoperative impaired pulsatility of LH secretion was probably a central effect of hyperprolactinemia. {J Clin Endocrinol Metab 62: 1044, 1986) T HE MAIN disturbances provoked by hyperprolactinemia in the human concern the hypothalamopituitary-gonadal axis. In the rats, dopamine turnover in the median eminence is increased by hyperprolactinemia, probably by a short loop feedback (1, 2). In man, dopamine infusion reduces serum LH concentrations (3), as well as the frequency of LH pulses (4). Furthermore, hyperprolactinemia is associated with a reduction in frequency or absence of LH pulses (5-8). Normalization of PRL with bromocriptine is followed by restoration of LH pulsatility (5-8), but this action may be due to a central action of bromocriptine rather than a consequence of reduced PRL secretion.Recently, LH pulsatility was found to be restored after transsphenoidal surgery (9). However, since that restoration occurred after resumption of menses and normal ovulatory function, it remained uncertain whether the postoperative increase in the number of LH peaks was due to PRL normalization or to an elevation of serum estradiol (E 2 ) levels. Indeed, the LH positive feedback response to estrogens is impaired in hyperprolactinemia (10) and restored after bromocriptine (11).

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Hyperprolactinemic Anovulatory Syndrome

Cited by 31 publications

References 0 publications

Hyperprolactinaemia and its Comparision with Hypothyroidism in Primary Infertile Women

Hyperprolactinaemia and its Comparision with Hypothyroidism in Primary Infertile Women

Cabergoline treatment rapidly improves gonadal function in hyperprolactinemic males: a comparison with bromocriptine

Early Normalization of Luteinizing Hormone Pulsatility after Successful Transsphenoidal Surgery in Women with Microprolactinomas

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