Hyperpyrexia During Anaesthesia

Abstract

Preliminary Communications IBAzT=Each patient had two exercise tests-one without medication and the other with 20 mg. of disodium cromoglycate (especially supplied without isoprenaline) inhaled 15 minutes before the exercise. In two patients the tests were repeated. Only one exercise test was carried out in a day. RESULTSThe results obtained in the eight patients are set out in Fig. 1. The effect of exercise with and without medication on F.E.V.1 is reproducible, and this is shown in Fig. 2 Hyperpyrexia During Anaesthesia Brit. med.J., 1968, 3, 594-595 S ummary: Work in pigs has shown that malignant hyperpyrexia during anaesthesia may occur without suxamethonium having been given. A virtually constant feature in reported cases and in our own observations is that all subjects developing hyperpyrexia had received nitrous oxide and halothane.The baffling and frightening complication of malignant hyperpyrexia occurring during anaesthesia has been described in humans by many authors (Cullen, 1966 ;Davies and Graves, 1966;Hogg, and Renwick, 1966; Lavoie, 1966;Relton et al.., 1966;Thut and Davenport, 1966;Purkis et al., 1967) stiffly extended, the muscles in extreme spasm in a way similar to that described by Hall et al. (1966) in their pigs and by the Canadian workers (Cullen, 1966 ;Davies and Graves, 1966;Hogg and Renwick, 1966; Lavoie, 1966;Relton et al., 1966;Thut and Davenport, 1966;Purkis et al., 1967) in the hyperpyrexial humans following the suxamethonium they postulated as being responsible for this condition. We did not observe any marked change in pulmonary compliance.Cultures of blood taken from the first two pigs which displayed this syndrome were negative. In the last two pigs the administration of nitrous oxide and halothane was discontinued as soon as the condition became evident. From then on oxygen

Hipertermia maligna. Aspectos históricos

“…Rev Chil Anest 2017; 46: [19][20][21][22][23][24] Prólogo L a hipertermia maligna es una miopatía de ocurrencia infrecuente que ha sido catalogada como una enfermedad farmacogenética. Los portadores no aparentan tener una patología muscular pero la afección se gatillará frente a la exposición a anestésicos inhalatorios y relajantes musculares depolarizantes (Succinilcolina).…”

“…Trascendental fue el hecho que desde principios del siglo XX se conocía que ciertas razas porcinas que eran frecuentemente utilizados para cirugía experimental, desarrollaban frente a episodios de stress o al ser anestesiados, un mortal cuadro de hipertermia 19,20 . Estos animales tenían una patología muscular y se transformaron en el modelo empírico ideal para el estudio de la hipertermia maligna 21,22 . Villiers se había visto involucrado previamente en otra hazaña.…”