Hypersensitivity Caused by Synthetic Thyroid Hormones in a Hypothyroid Patient With Hashimoto's Thyroiditis

Occurrence of thyroxine tablet (Thyradin S^®) - induced liver dysfunction in a patient with subclinical hypothyroidism

“…Despite approximately 800,000 people taking this drug per year in Japan (information provided by ASKA Pharmaceutical Co., Ltd.), to our knowledge, there are only three reports in the English literature of liver injury suspected due to L-T4 [2,3,4], but all reports ity of the drug lymphocyte stimulation test is 60-70%, based mainly on the analysis of β-lactam hypersensitivity [8]. However, the sensitivity of the drug lymphocyte stimulation test depends on each tested drug [9], and the sensitivity and specificity of the test for L-T4-induced liver injury is not yet known.…”

Liver Injury Induced by Levothyroxine in a Patient with Primary Hypothyroidism

“…In general, levothyroxine is safe and well tolerated by patients, except for the possibility of developing osteoporosis in postmenopausal patients with excessive doses (1). However, it has been known that administration of levothyroxine could cause liver injury, although scarcely reported (4)(5)(6) (Fig. 2a).…”

Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog

“…In that case the dog apparently suffered an idiosyncratic reaction to one of the inactive ingredients of the thyroid supplement rather than the hormone itself. Despite numerous discussions of such a reaction on professional medical sites, the human literature contains a limited number of published cases . Interestingly, most human cases appear to be “immediate” reactions (i.e.…”

“…Adult‐onset canine hypothyroidism is an immune‐mediated disease for which some genetic predispositions, including MHC II, have been suggested . Reported cases of allergic reactions to thyroid supplements in human medicine have included no, or limited, investigations of the specific target ingredient or its exact pathogenesis …”