Hypersensitivity to Chironomid Larvae in a Nonatopic Patient: Safe Diagnosis Tools to Identify a Potent Allergen

Vecillas, Leticia de las; Bartolomé-Zavala, Borja; Asensio, Esther; Segundo, David San; Rodríguez, F.; Montecchiani, Vittoria; Antón, E.

doi:10.18176/jiaci.0250

Cited by 1 publication

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“…Their function is to facilitate the parasite's infiltration through the digestive mucosa of its host. Ani s 1, Ani s 4, Ani s 5, Ani s 6, Ani s 7, Ani s 8, Ani s 9 and Ani s 13 can induce both sensitization and elicitation of allergic symptoms 1029–1031 . Three of these are considered major allergens, Ani s 1, an inhibitor of Kunitz‐type serine proteases, Ani s 7, a protein of unknown biological function and Ani s 13, a protein of haemoglobin function.…”

Section: B12 – Allergy To Fish and Anisakis Simplexmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

119

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Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

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Section: B12 – Allergy To Fish and Anisakis Simplexmentioning

confidence: 99%