Hypersensitivity to maize pollen

Gonzalo-Garijo, M A; Pérez-Calderón, Remedios; Muñoz‐Rodríguez, Adolfo F.; Molina, Rafael Tormo; Silva-Palacios, Inmaculada

doi:10.1046/j.1398-9995.2003.00396.x

Cited by 13 publications

(10 citation statements)

References 4 publications

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“…Although cultivated for a long time, exclusively maize allergic patients were very rarely reported [27,28] even though the crossreactive proteins are homologous to allergenic grass pollen proteins. We identified IgE crossreactivity of the group 12 allergens (profilins) in maize, which showed a high sequence identity between both plant species of 80.6%.…”

Section: Discussionmentioning

confidence: 99%

Proteome analysis of maize pollen for allergy-relevant components

et al. 2006

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Over the last few decades, the cultivation of maize (Zea mays) has strongly increased in Central Europe. We therefore decided to study the allergen composition and the allergenic potency of its pollen in comparison with pollen from timothy grass (Phleum pratense), a typical representative of the native grasses. We found that 65% of the sera reactive to timothy pollen also bound to maize pollen proteins. By using 2-DE immunoblotting, followed by incubation with mAbs directed against known allergens or protein sequencing, those IgE-reactive components were further classified. Although novel, maize-specific pollen allergens could not be found, the presence of crossreacting allergens belonging to groups 1 and 13 (Zea m 1 and 13), both having high IgE prevalence, as well as the presence of the less important group 3 and 12 allergens was found. The structural variability of Zea m 1 and Zea m 13 was determined by sequencing clones isolated from a maize pollen cDNA library. This revealed sequence identities of 72 and 70%, respectively, to the corresponding Phl p 1 and Phl p 13 allergens of timothy grass pollen. IgE-crossreactivity was further studied using immunoblot inhibition tests. Here, timothy pollen extract completely blocked IgE binding to maize, whereas maize pollen extract blocked IgE reactivity to only some timothy pollen allergens.

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Section: Discussionmentioning

confidence: 99%

Proteome analysis of maize pollen for allergy-relevant components

et al. 2006

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“…Gonzalo-Garijo et al4 reported a case of hypersensitivity to maize pollen, and Freeman reported cases of oral corn pollen hypersensitivity in Americans that received allergen-specific immunotherapy 5. However, there have been no known reports of occupational rhinitis induced by maize pollen.…”

Section: Introductionmentioning

confidence: 99%

A Case of Occupational Rhinitis Induced by Maize Pollen Exposure in a Farmer: Detection of IgE-Binding Components

Sung

Lee

Yong

et al. 2012

Allergy Asthma Immunol Res

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Corn is a major staple food, along with rice and wheat, in many parts of the world. There are several reports of hypersensitivity to maize pollen. However, cases of occupational allergic rhinitis induced by inhalation of maize pollen are very rare. We herein report the case of a 67-year-old male with occupational rhinitis caused by occupational exposure to maize pollen in a cornfield. He showed positive responses to maize pollen, as well as grass pollens, in skin prick tests. A high level of serum immunoglobulin E (IgE) specific to maize pollen extracts was detected by an enzyme-linked immunosorbent assay (ELISA). Laboratory tests showed a high serum level of total IgE (724 kU/L) and a high level of IgE specific to maize pollen (8.32 kU/L) using the Immuno-CAP system. Occupational rhinitis was confirmed by a nasal provocation test with maize pollen extracts. IgE ELISA inhibition tests showed antibody cross-reactivity between maize pollen and grass pollen extracts. IgE immunoblotting using maize pollen extracts demonstrated a 27 kDa IgE-binding component. These findings suggest that maize pollen can induce IgE-mediated occupational rhinitis in exposed workers.

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“…Respiratory symptoms caused by its pollen,4,5,7 occupational asthma and rhinoconjunctivitis due to its flour,2,3,8 contact urticaria,9 and food allergy due to maize ingestion1,10 have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Zea m 13 (poly-galacturonase) and Zea m 12 (profilin) are also pollen allergens 4. Zea m 14 (LTP) is a major food allergen,11 whereas α-amylase trypsin inhibitor7 and Zea m 25 (thioredoxin) are minor food allergens 12,13…”

Section: Discussionmentioning

confidence: 99%

Occupational Rhinoconjunctivitis due to Maize in a Snack Processor: A Cross-Reactivity Study Between Lipid Transfer Proteins From Different Cereals and Peach

Guillén

Paredes

Palacín³

et al. 2014

Allergy Asthma Immunol Res

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We report the case of a snack processor who developed occupational rhinoconjunctivitis due to maize brand exposure during the extrusion process, and who experienced abdominal pain upon drinking beer. The allergens implicated and the cross-reactivity between non-specific lipid transfer proteins (LTPs) from different cereals and peach were investigated. Skin prick tests and specific IgE to cereal flours, pulmonary functions tests and specific conjunctival and inhalation challenges to maize extract were performed. In vitro studies included IgE immunoblotting and ELISA inhibition assays. Skin prick tests with maize flour, maize brand and wheat flour extracts were positive, whereas serum specific IgE was positive only to maize flour. Specific inhalation challenge (SIC) to maize flour did not elicit an asthmatic reaction; however, conjunctival challenge test with the same extract was positive. Patient's serum recognized IgE-binding bands in the maize and beer extracts corresponding to LTPs. In the ELISA inhibition assays, a significant degree of allergenic cross-reactivity was found between maize and beer LTPs, whereas no cross-reactivity was observed between maize LTP and wheat and peach LTPs.

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Hypersensitivity to maize pollen

Cited by 13 publications

References 4 publications

Proteome analysis of maize pollen for allergy-relevant components

Proteome analysis of maize pollen for allergy-relevant components

A Case of Occupational Rhinitis Induced by Maize Pollen Exposure in a Farmer: Detection of IgE-Binding Components

Occupational Rhinoconjunctivitis due to Maize in a Snack Processor: A Cross-Reactivity Study Between Lipid Transfer Proteins From Different Cereals and Peach

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