Hyperspectral imaging in quality control of inkjet printed personalised dosage forms

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

“…Recently, multiple methods have been described for non-destructive API content analysis in printed dosage forms. Vakili et al used near-infrared chemical imaging for content analysis of IJP theophylline using copy paper as the model substrate (10). Researchers from the same group have used a colorimetric technique for content determination of IJP propranolol with colorant added, using edible rice paper and edible icing sheets as the substrates (11) and was also used for quantitative determination of IJP vitamin B2 doses on edible rice paper and copy paper (12).…”

Orodispersible films: Towards drug delivery in special populations

“…Due to the lack of specific guidelines, USP 1 or 2 dissolution apparatus is currently used as standard assays, although several criticisms have been made to the high volumes of dissolution/disintegration media employed (Garsuch and Breitkreutz, 2010). manufacturing opportunity for personalised ODF manufacture (Cheow et al, 2015;Genina et al, 2013b;Sandler et al, 2011;Vakili et al, 2015). Current studies are being conducted on the application of the inkjet printing technology to produce dose-flexible oral films (Alomari et al, 2014).…”

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

“…However, in both methods, the structure needs to be dissolved in a suitable solvent. Vakili et al have used near infra-red (NIR) hyperspectral imaging technique as a tool to quantify the drug content in 3D printed dosage forms of each printed layer [159]. The tool is currently heavily used in the agricultural and food industries for quality and safety assessments.…”

“…The tool is currently heavily used in the agricultural and food industries for quality and safety assessments. With future research, NIR hyperspectral imaging can be used as a reliable, rapid and non-destructive method to validate the dosage of printed pharmaceuticals and ensure that the pharmaceuticals are meeting quality standards [159]. Kyobula et al used Raman spectroscopy to understand the drug distribution on the printed structure [33].…”