Hypertension

Guyton, Arthur C.

doi:10.1001/archneur.1988.00520260064021

Cited by 13 publications

References 21 publications

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Renal Nerves and Long‐Term Control of Arterial Pressure

Osborn

Foss

2017

Comprehensive Physiology

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The objective of this review is to provide an in-depth evaluation of how renal nerves regulate renal and cardiovascular function with a focus on long-term control of arterial pressure. We begin by reviewing the anatomy of renal nerves and then briefly discuss how the activity of renal nerves affects renal function. Current methods for measurement and quantification of efferent renal-nerve activity (ERNA) in animals and humans are discussed. Acute regulation of ERNA by classical neural reflexes as well and hormonal inputs to the brain is reviewed. The role of renal nerves in long-term control of arterial pressure in normotensive and hypertensive animals (and humans) is then reviewed with a focus on studies utilizing continuous long-term monitoring of arterial pressure. This includes a review of the effect of renal-nerve ablation on long-term control of arterial pressure in experimental animals as well as humans with drug-resistant hypertension. The extent to which changes in arterial pressure are due to ablation of renal afferent or efferent nerves are reviewed. We conclude by discussing the importance of renal nerves, relative to sympathetic activity to other vascular beds, in long-term control of arterial pressure and hypertension and propose directions for future research in this field. © 2017 American Physiological Society. Compr Physiol 7:263-320, 2017.

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Renal Nerves and Long‐Term Control of Arterial Pressure

Osborn

Foss

2017

Comprehensive Physiology

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Long-term lowering of blood pressure after carotid and vertebrobasilar ischemic stroke

et al. 1996

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We followed up 107 patients experiencing a first-ever ischemic stroke after having been affected by essential hypertension for at least one year, in order to analyze the phenomenon of post-stroke blood pressure lowering. Of the 82 patients still surviving after three months of follow-up, 44 (54%) had normal arterial blood pressure values. There were no significant differences between these normotensive patients and the 38 with high blood pressure in terms of cerebrovascular risk factors or disability, but blood pressure normalized in 34 of the 54 patients experiencing a carotid stroke (63%) and in only 10 of the 28 experiencing vertebrobasilar stroke (36%) (p = 0.035). These data may offer a starting point for further studies of the neurogenesis of arterial hypertension.

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Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms

Grundemar

Håkanson

1993

General Pharmacology: The Vascular System

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Hypertension

Cited by 13 publications

References 21 publications

Renal Nerves and Long‐Term Control of Arterial Pressure

Renal Nerves and Long‐Term Control of Arterial Pressure

Long-term lowering of blood pressure after carotid and vertebrobasilar ischemic stroke

Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms

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