Hypertension detection and follow-up program. Baseline electrocardiographic characteristics of the hypertensive participants.

Prineas, Ronald J.; Castle, C. Hilmon; Curb, J. David; Harrist, Ronald B.; Lewin, Andrew; Stamler, Jeremiah

doi:10.1161/01.hyp.5.6_pt_2.iv160

Cited by 26 publications

(17 citation statements)

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“…Later, more descriptions with detailed Minnesota coding of ECG findings appeared for more than 10,000 black and white men and women in the Hypertension Detection and Follow-up Program 12 with specific abnormalities tabulated by age race and sex and showed generally that black men had the greatest proportion of abnormalities present. This was a cohort of hypertensive persons of whom 79% had an ECG abnormality.…”

Section: Discussionmentioning

confidence: 99%

United States National Prevalence of Electrocardiographic Abnormalities in Black and White Middle-Age (45- to 64-Year) and Older (≥65-Year) Adults (from the Reasons for Geographic and Racial Differences in Stroke Study)

Prineas

Soliman

et al. 2012

The American Journal of Cardiology

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A US national sample of 20,962 participants (57% women, 44% blacks) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study provided general population estimates for ECG abnormalities among black and white men and women. Participants were recruited during 2003–2007 by random selection from a commercially available nationwide list, with oversampling of blacks and persons from the stroke belt for a cooperation rate of 49%. Measurement of risk factors and 12-lead ECGs (centrally coded using Minnesota Code criteria) showed 28% had at least one major ECG abnormality. Prevalence of abnormalities was higher (35%+) for those 65 years and older with no differences between blacks and whites. However, among men less than 65 years, blacks had more major abnormalities than whites, most notably for atrial fibrillation, major Q waves and left ventricular hypertrophy (LVH). Men generally had more ECG abnormalities than women. The most common ECG abnormalities were T-wave abnormalities. Average heart rate corrected QT interval was longer in women than men, similar in whites and blacks and increased with age, whereas the average heart rate was higher in women than men and in blacks than whites and decreased with age. The prevalence of ECG abnormalities was related to hypertension, diabetes, blood pressure level and age. In conclusion, black men and women in the US have a significantly higher prevalence of ECG abnormalities than whites at ages 45–64 but these proportions, although larger, tend to equalize or reverse after age 65.

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Section: Discussionmentioning

confidence: 99%

United States National Prevalence of Electrocardiographic Abnormalities in Black and White Middle-Age (45- to 64-Year) and Older (≥65-Year) Adults (from the Reasons for Geographic and Racial Differences in Stroke Study)

Prineas

Soliman

et al. 2012

The American Journal of Cardiology

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“…Resting electrocardiograms were classified as showing major, minor, or no abnormalities, according to the standardized definitions used in the Hypertension Detection and Follow-up Program. 10 The study has been approved periodically by the Northwestern University Institutional Review Board.…”

Section: Study Samplementioning

confidence: 99%

Risk Factor Burden in Middle Age and Lifetime Risks for Cardiovascular and Non-Cardiovascular Death (Chicago Heart Association Detection Project in Industry)

Lloyd‐Jones

Dyer

Wang

et al. 2007

The American Journal of Cardiology

130

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Data are sparse regarding the association of risk factor burden in middle age with lifetime risks for cardiovascular disease (CVD) and non-CVD death. We straitified participants of the Chicago Heart Association Detection Project in Industry aged 40 to 59 years in 1967-1973 into 5 groups based on risk factor burden: favorable risk factor profile (untreated blood pressure ≤120/≤80 mm Hg, total cholesterol <200 mg/dL, non-smoking, and body mass index [BMI] <25 kg/m 2 ); 0 elevated but ≥1 unfavorable; or any 1, any 2, or ≥3 elevated (systolic ≥140 or diastolic ≥90 mm Hg, or treated hypertension; total cholesterol ≥240 mg/dL; current smoking; or BMI ≥30 kg/m 2 ). We estimated remaining lifetime risks for CVD and non-CVD death through age 85 years. We followed 8033 men and 6493 women for 409,987 person-years; 2582 died of CVD and 3955 died of non-CVD causes. Greater risk factor burden was associated with higher incidence of both CVD and non-CVD death. Compared with participants with ≥3 risk factors, those with favorable profiles had substantially lower lifetime risks for CVD death (20.5% vs. 35.2% in men, 6.7% vs. 31.9% in women) and markedly longer median Kaplan-Meier survival (>35 vs. 26 years in men, >35 vs. 28 years in women). In conclusion, having favorable risk factors in middle age is associated with lower lifetime risk for CVD death and markedly longer survival. These results should encourage efforts aimed at preventing development of risk factors in younger individuals to decrease CVD mortality and promote longevity.

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“…Resting electrocardiograms (ECGs) were classified as showing major, minor, or no abnormalities based on criteria of the Hypertension Detection and Follow-up Program. 18…”

Section: Participants and Baseline Examinationmentioning

confidence: 99%

Favorable Cardiovascular Risk Profile in Middle Age and Health-Related Quality of Life in Older Age

Daviglus

Liu²,

Pirzada³

et al. 2003

Arch Intern Med

115

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Hypertension detection and follow-up program. Baseline electrocardiographic characteristics of the hypertensive participants.

Cited by 26 publications

References 0 publications

United States National Prevalence of Electrocardiographic Abnormalities in Black and White Middle-Age (45- to 64-Year) and Older (≥65-Year) Adults (from the Reasons for Geographic and Racial Differences in Stroke Study)

United States National Prevalence of Electrocardiographic Abnormalities in Black and White Middle-Age (45- to 64-Year) and Older (≥65-Year) Adults (from the Reasons for Geographic and Racial Differences in Stroke Study)

Risk Factor Burden in Middle Age and Lifetime Risks for Cardiovascular and Non-Cardiovascular Death (Chicago Heart Association Detection Project in Industry)

Favorable Cardiovascular Risk Profile in Middle Age and Health-Related Quality of Life in Older Age

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