HYPERTENSION IN PREGNANCY: Current Concepts of Preeclampsia

Witlin, Andrea G.; Sibai, Bahaeddine M

doi:10.1146/annurev.med.48.1.115

Cited by 64 publications

(40 citation statements)

References 44 publications

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“…Hypertensive disorders are the most common medical complications during pregnancy and are associated with high maternofetal mortality and morbidity. Collectively, these disorders complicate 5-10% of all pregnancies 3 . One way to reduce the impact of arterial hypertension on maternal mortality is to establish the correct diagnosis of preeclampsia, and to proceed with an early intervention when it is diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Association of serum calcium and uric acid level with hypertensive disorders of pregnancy [pre eclampsia and eclampsia] and there correlation with disease severity

Koley¹

2013

IOSR-JDMS

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Section: Introductionmentioning

confidence: 99%

Association of serum calcium and uric acid level with hypertensive disorders of pregnancy [pre eclampsia and eclampsia] and there correlation with disease severity

Koley¹

2013

IOSR-JDMS

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“…The disease is characterized by the development, in the latter half of pregnancy, of new-onset hypertension that resolves postpartum [1][2][3]. PE/E is a leading cause of maternal mortality and morbidity, particularly in developing countries [4].…”

Section: Introductionmentioning

confidence: 99%

Pre-Eclampsia: Maternal Risk Factors and Perinatal Outcome

et al. 2003

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Objective: The aim of this study was to throw light on the incidence of pre-eclampsia (PE) in women attending for care and delivery at a hospital in Saudi Arabia, and analyze the maternal risk factors and outcome of mothers and neonates in pregnancies complicated by PE. Methods: This retrospective study involved almost all women (n = 27,787) who delivered at King Fahad Hospital of the University in a 10-year period (1992–2001). The maternal records were reviewed for age, parity, gestational age, mode of delivery, antenatal care, onset of PE, severity of proteinuria, and the frequency of antenatal and intrapartum complications. The neonatal records were reviewed for perinatal outcome including birth weight, frequency of stillbirths, and neonatal deaths. Results: Among the study cohort of maternities, 685 women, i.e. 2.47%, were diagnosed as having PE among whom a high proportion (42.0%) were nulliparous women. Similarly, PE was encountered at a high percentage (40.0%) in women at the extreme of their reproductive age (< 20 and >40 years), and more women with PE delivered prematurely (30.2%) as compared to healthy controls (13.5%). Spontaneous vaginal deliveries were less frequent in women with PE (69.2%) as compared with healthy controls (86.2%). Instrumental deliveries, with spontaneous labor, amounted to 15.9% in women with PE, but they comprised only 2.9% in healthy women. The deliveries were more likely to be induced (22.8%) or be performed by cesarean section (14.9%) in women with PE than in healthy controls (6.8% and 9.6%). Placental abruption was the most common maternal complication (12.6%) in women with PE, followed by oligouria (7.9%), coagulopathy (6.0%), and renal failure (4.1%). The perinatal outcome of maternities with PE shows that stillbirths (2.34%) and early neonatal deaths (1.02%) comprised an overall mortality rate of 33.6 per 1,000. More stillbirths and neonatal deaths showed a tendency to be associated with the severe form of PE (diastolic BP ≧120), as compared with the mild form (diastolic BP 90–110). Stillbirths and neonatal deaths appear to be associated with women who had no or irregular antenatal care and whose proteinuria amounted to or exceeded 3 g per 24 h, when delivery occurred at 28th gestational week or less, and when the birth-weight of the neonates was between 500 and 1,000 g. Conclusion: We document a hospital-based incidence rate of PE of 2.47%, with a high proportion of PE cases occurring among nulliparous women and those at the extreme ends of the reproductive age. More maternal and neonatal complications were encountered in women with PE when the PE was severe, when the pregnancy had to be terminated early, when there was no regular antenatal care, the birth-weight was low, or the proteinuria was severe.

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“…The leading cause of IUGR in developed countries is uteroplacental insufficiency (UPI) (1). The association between IUGR and defective immune function is an important public health issue because UPI affects 5-9% of all pregnancies (2,3).…”

mentioning

confidence: 99%

Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats

Contreras

Hale

et al. 2011

Pediatr Res

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Intrauterine growth restricted (IUGR) infants have increased susceptibility to infection associated with higher risk of illness and death. Dual specificity phosphatase 1 (DUSP1), which is transcribed in the thymus, increases in quantity as T cells mature and differentiate into CD4ϩ cells. Little is known about how IUGR affects DUSP1 levels and T-cell subpopulations over time. We hypothesized that IUGR would decrease cell count, CD4ϩ and CD8ϩ subpopulations of T lymphocytes, and DUSP1 levels in IUGR rat thymus and spleen. Bilateral uterine artery ligation produced IUGR rats. Thymus and spleen were harvested at P0 and P21. Flow cytometry was used to compare CD4ϩ and CD8ϩ lymphocyte populations. Real-time RT-PCR and Western blotting were used to determine DUSP1 quantity. IUGR significantly decreased total cell count in P0 and P21 IUGR male and female thymus. IUGR significantly increased CD4ϩ cells in IUGR P0 males and females, significantly decreased CD4ϩ cells in P21 female thymus, and significantly altered DUSP1 levels in the IUGR female thymus at P0 and P21, although it is not yet known whether the change in DUSP1 levels is due to a change in the level per cell or to a change in cellular composition of the thymus. (Pediatr Res 70: 123-129, 2011)

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HYPERTENSION IN PREGNANCY: Current Concepts of Preeclampsia

Cited by 64 publications

References 44 publications

Association of serum calcium and uric acid level with hypertensive disorders of pregnancy [pre eclampsia and eclampsia] and there correlation with disease severity

Association of serum calcium and uric acid level with hypertensive disorders of pregnancy [pre eclampsia and eclampsia] and there correlation with disease severity

Pre-Eclampsia: Maternal Risk Factors and Perinatal Outcome

Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats

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