Hypertension Management in the High Cardiovascular Risk Population

Maraj, Ilir; Makaryus, John N.; Ashkar, Ali A.; McFarlane, Samy I.; Makaryus, Amgad N.

doi:10.1155/2013/382802

Cited by 15 publications

(16 citation statements)

References 47 publications

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“…The existence of a relationship between complications associated to MS and cardiovascular diseases is widely known, being hypertension one of the most important risk factor for development of cardiovascular pathologies (Maraj, Makaryus, Ashkar, McFarlane, & Makaryus, ). In the present study, SBP was slightly higher in 20 weeks‐old ZFR than ZLR, in agreement to that found by other researchers; in fact, ZFR are considered as pre‐hypertensive animals at young ages and hypertensive animals since 25–30 weeks of life (Belobrajdic, Lam, Mano, Wittert, & Bird, ; Oltman et al, ).…”

Section: Discussionmentioning

confidence: 99%

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

et al. 2019

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Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium‐emitted fluorescence, NOX‐1 mRNA levels by qRT‐PCR, angiotensin‐converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress. Practical applications Egg white is a good source of bioactive peptides, some of them with high antioxidant activity. They may be used as functional foods ingredients and could serve as an alternative therapeutic option to decrease some Metabolic Syndrome‐related complications. This study suggests that these hydrolysates could be an interesting non‐pharmacological tool to control cardiovascular complications related to Metabolic Syndrome.

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Section: Discussionmentioning

confidence: 99%

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

et al. 2019

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“…Evidence has shown that the impact of hypertension in cardiovascular morbidity and mortality is higher than any other cardiovascular risk factors, including obesity, dyslipidemia, inflammation and hypercoagulable state, etc. (Maraj et al, 2013). For patients in the age range of 40-90 years, each 20/10 mmHg rise in BP doubles the risk of fatal coronary events (Ismail and Makaryus, 2011).…”

Section: Discussionmentioning

confidence: 99%

The impact of the improvement of insomnia on blood pressure in hypertensive patients

Yang

et al. 2016

Journal of Sleep Research

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Summary This study investigated the impact of the improvement of insomnia on the blood pressure levels of hypertensive patients. A total of 402 patients with a diagnosis of insomnia and hypertension were selected and randomly divided into two groups. The treatment group (202 cases) received standard anti‐hypertensive treatment with Estazolam, and the control group (200 cases) received standard anti‐hypertensive treatment with placebo. The sedentary diastolic and systolic blood pressures were measured before the treatment and every 7 days during the experiment. To assess the sleep quality and anxiety and depression levels of patients, the scores of the Pittsburgh Sleep Quality Index, the Hamilton Anxiety Rating Scale and the Hamilton Depression Scale‐17 were reported at the same time points. At the conclusion of the experiment, the Pittsburgh Sleep Quality Index, Hamilton Anxiety Rating Scale and Hamilton Depression Scale‐17 scores of the treatment group were significantly lower than those of the control group (P < 0.001). The insomnia treatment efficacy of Estazolam in the treatment group was 67.3%, significantly higher than that (14.0%) of the control (P < 0.001). The blood pressure of the treatment group showed significant improvement throughout the experiment. By Day 28, the decrease of sedentary diastolic and systolic blood pressures in the treatment group was significantly greater than that of the control (sedentary systolic blood pressure: 10.5 ± 3.9 versus 3.4 ± 2.5 mmHg; sedentary diastolic blood pressure: 8.1 ± 3.6 versus 2.7 ± 2.1 mmHg, P < 0.001), and the compliance rate of goal blood pressure (< 140/90 mmHg) was 74.8% with Estazolam, compared with 50.5% with placebo (P < 0.001). Thus, the current findings indicated that the improvement of insomnia can significantly help lower blood pressure in hypertensive patients.

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“…Candida akan menimbulkan infeksi bila berkoloni, menginvasi dan bermultiplikasi. 10,21,22 Tahap adhesi merupakan interaksi antara Candida dengan host yang merupakan syarat terjadinya kolonisasi dan invasi. Adhesin merupakan molekul pada permukaan candida yang memfasilitasi adhesi ke permukaan host, meliputi protein ALS (Agglutinin-like sequence), HWP1 (hyphal wall protein).…”

Section: Pembahasanunclassified

“…25 Banyak obat antijamur tersedia untuk pengobatan kandidiasis oral, meliputi poliene seperti nistatin, amfoterisin B serta azol seperti ketokonazol (imidazol) dan flukonazol (triazol). 21,26 Nistatin merupakan macrolide poliene aktifmembran yang dihasilkan oleh Streptomyces noursei, memiliki aktivitas fungisida terhadap C. albicans spp. Nistatin tidak diabsorbsi pada saluran gastrointestinal ketika diberikan secara oral, penggunaan nistatin secara topikal merupakan rute pemberian yang paling umum dalam kedokteran gigi.…”

Section: Pembahasanunclassified

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<p>Manajemen perawatan pasien dengan manifestasi oral pasca difteri</p><p>Medical management of patient with post diphtheria oral manifestations</p>

Munthe

Dewi

2019

J Ked Gi Unpad

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Difteri kembali mewabah di Indonesia. Kementerian Kesehatan menetapkan status kejadian luar biasa dengan jumlah 907 kasus dari 29 provinsi hingga 25 Desember 2017. Jawa Barat merupakan provinsi dengan kasus difteri kedua terbanyak dengan jumlah 123 kasus dan jumlah kematian 13 kasus. Difteri merupakan penyakit infeksi akut disebabkan Corynebacterium diphtheriae menghasilkan eksotoksin penyebab kerusakan jaringan, pembentukan pseudomembran dan edema jalan nafas dapat berakhir pada kematian. Penurunan kondisi umum ini dapat menjadi faktor predisposisi mengubah Candida albicans komensal di rongga mulut menjadi patogen oportunistik sehingga mampu menyebabkan infeksi yang memperberat kondisi pasien. Tujuan laporan kasus ini untuk membahas manajemen perawatan multidisiplin ilmu pada pasien dengan manifestasi oral pasca difteri. Laporan kasus: Pasien laki-laki berusia 57 tahun dirujuk dari Departemen Ilmu Penyakit Dalam dengan diagnosis tonsilitis difteri disertai kandidiasis orofaringeal. Terdapat keluhan nyeri menelan, disertai timbulnya multipel ulser dan bercak putih pada mukosa oral, serta plak tebal putih kekuningan di posterior rongga mulut. Diagnosis ditegakkan sebagai lesi oral terkait difteri disertai kandidiasis orofaringeal. Sakit menelan menyebabkan pasien kekurangan asupan nutrisi. Medikasi yang diberikan meliputi nistatin oral suspensi, multivitamin, antiseptik klorheksidin glukonat 0,2%, serta diet cair tinggi kalori. Ulser mengalami penyembuhan, bercak putih menipis dan hilang dalam waktu 6 hari pemberian terapi. Manajemen perawatan lesi oral yang adekuat melalui terapi farmakologis, terapi penunjang dan edukasi yang komprehensif memiliki efikasi bagi pasien. Simpulan: Manajemen perawatan dengan manifestasi oral difteri berhasil dilakukan dengan melalui terapi farmakologis, terapi penunjang dan edukasi yang komprehensif. penekanan kebersihan mulut pasien, karena kebersihan gigi dan mulut dapat mencegah timbulnya infeksi oportunistik yang dapat memperparah keadaan rongga mulut.

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Hypertension Management in the High Cardiovascular Risk Population

Cited by 15 publications

References 47 publications

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

The impact of the improvement of insomnia on blood pressure in hypertensive patients

<p>Manajemen perawatan pasien dengan manifestasi oral pasca difteri</p><p>Medical management of patient with post diphtheria oral manifestations</p>

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