Hyperthyroidism and Pregnancy

Kobaly, Kristen

doi:10.1016/j.ecl.2019.05.002

Cited by 37 publications

(32 citation statements)

References 56 publications

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“…In the present study, the prevalence of hyperthyroidism was estimated to be 3.31% (overt [1.06%] and subclinical [2.56%]) in the present study. Other studies have reported that hyperthyroidism occurs in about 0.2-1.0% of all pregnancies, with overt hyperthyroidism occurring in 0.1 to 0.4% of pregnancies and subclinical in up to 1% of pregnancies [12,48,[61][62][63].…”

Section: Discussionmentioning

confidence: 99%

Thyroid dysfunction in Iranian pregnant women: a systematic review and meta-analysis

Sepasi

Rashidian

Shokri

et al. 2020

BMC Pregnancy Childbirth

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Background: Thyroid dysfunction during pregnancy is associated with adverse outcomes for both mother and fetus. The present meta-analysis was conducted to evaluate thyroid dysfunction in Iranian pregnant women. Methods: We registered this review at PROSPERO (registration number: CRD42020166655). The research steps in this systematic review and meta-analysis were performed according to the MOOSE protocol, and finally, reports were provided based on the PRISMA guidelines. The literature search was performed in October 2019 using the international online databases, including Web of Science, Ovid, Science Direct, Scopus, EMBASE, PubMed/Medline, Cochrane Library, EBSCO, CINAHL, Google Scholar as well as national databases were reviewed. Data were extracted after applying the inclusion and exclusion criteria and qualitative evaluation of the studies. I 2 index and Q test were used to assess differences in studies. All analyses were performed using Comprehensive Meta-Analysis Software. Pvalue less than 0.05 was considered statistically significant. We identified 1261 potential articles from the databases, and 426 articles remained after removing the duplicate and unrelated studies. After evaluating the full text, 52 articles were removed. Results: Finally, 19 eligible studies including 17,670 pregnant women included for meta-analysis. The prevalence of thyroid dysfunction in Iranian pregnant women was 18.10% (95%CI: 13.89-23.25). The prevalence of hypothyroidism, clinical hypothyroidism, and subclinical hypothyroidism in Iranian pregnant women was respectively estimated to be 13.01% (95%CI: 9.15-18.17), 1.35% (95%CI: 0.97-1.86) and 11.90% (95%CI: 7.40-18.57). The prevalence of hyperthyroidism, clinical hyperthyroidism, and subclinical hyperthyroidism in Iranian pregnant women was respectively estimated to be 3.31% (95%CI: 1.62-6.61), 1.06% (95%CI: 0.61-1.84) and 2.56% (95%CI: 0.90-7.05). The prevalence of anti-thyroperoxidase antibody was estimated to be 11.68% (95%CI: 7.92-16.89). Conclusion: The results of this meta-analysis showed a high prevalence of thyroid disorders, especially hypothyroidism. The decision to recommend thyroid screening during pregnancy for all women is still under debate, because the positive effects of treatment on pregnancy outcomes must be ensured. On the other hand, evidence about the effect of thyroid screening and treatment of thyroid disorders on pregnancy outcomes is still insufficient. Nevertheless, a large percentage of general practitioners, obstetricians and gynecologists perform screening procedures in Iran.

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Section: Discussionmentioning

confidence: 99%

Thyroid dysfunction in Iranian pregnant women: a systematic review and meta-analysis

Sepasi

Rashidian

Shokri

et al. 2020

BMC Pregnancy Childbirth

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“…If surgery is undertaken, hypothyroidism should be treated with levothyroxine to achieve a euthyroid state before trying to conceive. Next, according to the guideline by American Thyroid Association in 2017, a maternal serum determination of TRAb is recommended at initial thyroid function testing during early pregnancy among all women with a prior history of hyperthyroidism treated with surgery [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

A hypothyroid mother after subtotal thyroidectomy delivered a newborn with hyperthyroidism from fetal stage: a case report

Peng

Sun

Fan

et al. 2022

BMC Pregnancy Childbirth

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Background Neonatal hyperthyroidism is an extension of fetal disease. Most cases of neonatal hyperthyroidism are transient but may excessively harm multiple organ functions through the actions of maternal thyroid-stimulating hormone receptor antibodies on the neonatal thyroid gland. Case presentation The hyperthyroid mother underwent subtotal thyroidectomy before pregnancy and regularly took levothyroxine to avoid hypothyroidism, but still had a high-level thyroid-stimulating hormone receptor antibody (TRAb). The neonate suffered from hyperthyroidism due to the transplacental TRAb. After a regular medication schedule of an antithyroid drug, combined with a β-blocker to control the ventricular rate, the infant gradually recovered, allowing normal motor and intellectual development. Conclusions Maternal subtotal thyroidectomy cannot prevent the secretion of thyroid receptor antibodies, which may cause either hypothyroidism or hyperthyroidism. The balance between antithyroid drugs and levothyroxine is critical in clinical practice.

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“…The most common cause of maternal hyperthyroidism during pregnancy is Graves' disease [10]. An antibody called thyroid-stimulating immunoglobulin (TSI) levels increase and causes the thyroid to overreact.…”

Section: Methodsmentioning

confidence: 99%

The Follow-Up of Thyroid Disease in 188 Pregnant Women According to the Guidelines of ATA (American Thyroid Association) 2017

Yuksekdag¹,

Aysun²,

Yıldız³

et al. 2020

Reprod Med Int

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Background: Thyroid disease in pregnancy is a common clinical problem. Since the guidelines for the management of these disorders by the American Thyroid Association (ATA) were first published in 2011, significant clinical and scientific advances have occurred in the field. A major and substantial change in the new guidelines includes raising the upper limit in the normal thyroid function tests. For Thyroid Stimulating Hormone (TSH), the upper limit was 2.5 mU/L in the 2011 guidelines. Normal upper limit in pregnancy is raised to 4.0 mU/L in 2017 revision. In the present study, we evaluated our pregnant patients according to the ATA 2017 criteria. brain development is totally dependent on the maternal thyroid hormones [8]. Since congenital hypothyroidism is one of the most preventable causes of mental retardation, we insist on the necessity of frequent blood tests especially valid for the first 14 weeks. It is also vital to remember that iron and calci-

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Hyperthyroidism and Pregnancy

Cited by 37 publications

References 56 publications

Thyroid dysfunction in Iranian pregnant women: a systematic review and meta-analysis

Thyroid dysfunction in Iranian pregnant women: a systematic review and meta-analysis

A hypothyroid mother after subtotal thyroidectomy delivered a newborn with hyperthyroidism from fetal stage: a case report

The Follow-Up of Thyroid Disease in 188 Pregnant Women According to the Guidelines of ATA (American Thyroid Association) 2017

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