Hypertonic and Hyperoncotic Resuscitation from Severe Hemorrhagic Shock in Dogs

Resuscitation from hemorrhagic shock: Experimental model comparing normal saline, dextran, and hypertonic saline solutions

“…Overall mortality (21.8%) was comparable with that reported by others studies (29,30) using a similar model of hemorrhage and was not significantly different among treatment groups.…”

Early Hemodynamic and Renal Effects of Hemorrhagic Shock Resuscitation with Lactated Ringer’s Solution, Hydroxyethyl Starch, and Hypertonic Saline with or without 6% Dextran-70

“…Adding 6% dextran-70 to HS has been widely studied, both in clinical scenarios and in experimental research, and it has been demonstrated that there is an increase in plasma volume depending on the dextran solution [14]. Even though the infusion of HS and HSD in hemorrhaged animals quickly increases plasma volume, the blood volume remains less than the normal volume [10,15]. Consequently, the initial increases in CI and cardiac filling pressures after treatment were clearly less after HS and HSD solution administration compared with LR and HES solutions.…”

“…Velasco and colleagues [8] first reported that severe hemorrhagic shock can be effectively treated with hypertonic saline (HS). The addition of 6% dextran-70 to HS (HSD) has been shown to enhance the duration and intensity of volume expansion that is reached by HS and several groups have treated hemorrhagic shock with HSD [9,10].…”

Hypertonic Saline Solution Increases the Expression of Heat Shock Protein 70 and Improves Lung Inflammation Early After Reperfusion in a Rodent Model of Controlled Hemorrhage

“…Hypertonic saline (HS) solution was as effective as larger volumes of isotonic saline (IS) solution for restoring hemodynamic parameters in experimental models of hemorrhagic shock (9). More recently, other authors have proposed that resuscitation with HS solution could also modulate favorably the I-R injury, probably acting in the inflammatory process (10).…”