Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy

Abstract

: 26 cute pancreatitis is a sudden inflammation of the pancreas. It is related with severe complications and high mortality despite treatment. One of the most common causes of acute pancreatitis is hypertriglyceridemia (HTG). Hypertriglyceridemia is defined as triglyceride levels more than 150 mg/dl. In normal pregnancy, lipid profile can change in response to estrogen levels. But it is important to distinguish normal from abnormal rise. There are effective treatment choices during pregnancy such as dietary restriction of fat, intravenous heparin and insulin and plasmapheresis. CASE REPORTThe patient was admitted with epigastric pain, nausea and hypertension in the 31 st weeks of gestation. Fetal heart beats were present. On admission, her vital signs were normal except blood pressure which was 150/100 mmHg. She had diabetes mellitus and hepatosplenomegaly in history. Her liver function tests had increased occasionally during pregnancy. Cesarean delivery was performed and a 1375-g female infant was delivered with 1-minute Apgar score 7 and 5-minute Apgar score 9. Her laboratory studies showed hematocrit 30.6% (normal range 35-45%), white blood cell count 19.900 cells/µL (normal range 3700-10.000 cells/L), triglyceride 1108 mg/dL (normal range <150 mg/dL), amylase 252 U/L (normal range <100 U/L), lipase 1146 U/L (normal range <60 U/L), lactate dehydrogenase 3954 U/L (normal range <448 U/L) and slightly elevated liver and renal function tests. Hypertriglyceridemia-Induced Acute Pancreatitis During PregnancyA AB BS S T TR RA AC CT T Acute pancreatitis is a sudden inflammation of the pancreas. It is related with severe complications and high mortality despite treatment. One of the most common causes of acute pancreatitis is hypertriglyceridemia (HTG) that is defined as triglyceride levels more than 150 mg/dl. There are effective treatment choices during pregnancy such as dietary restriction of fat, intravenous heparin and insulin and plasmapheresis. We presented a patient with severe HTG induced pancreatitis during pregnancy. She was consulted with hypertension and epigastric pain in the 31st weeks of gestation. After birth, she was treated successfully with heparin, insulin and cessation of oral intake and total parenteral nutrition.K Ke ey yw wo or rd ds s: : Pancreatitis; hypertriglyceridemia; pre-eclampsia; pregnancy