Hypertrophic Cardiomyopathy

Côté, Diplomate Acvim Etienne; MacDonald, Diplomate Acvim Kristin A.; Meurs, Diplomate Acvim and Kathryn M.; Vmd, Diplomate Acvim Meg M. Sleeper

doi:10.1002/9781118785782.ch11

Cited by 16 publications

(52 citation statements)

References 228 publications

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“…When MCO, Ragdolls, and Persian cats are considered as blood donors their genetic predisposition for hypertrophic cardiomyopathy (HCM) must be considered [12]. Although the collection of a unit of blood for transfusion from healthy cats weighing more than 5 kg appears to be safe, it does lead to a decrease in arterial blood pressure, PCV, and heart rate [13], that could pose a risk to cats with cardiac diseases.…”

Section: Discussionmentioning

confidence: 99%

Signalment and Blood Types in Cats Being Evaluated as Blood Donors at Two Italian University Blood Banks

Spada

Miglio

Proverbio

et al. 2014

Veterinary Medicine International

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Data from potential feline blood donors presented at two university blood banks in Italy were recorded. Blood typing was performed using an immunochromatographic method. Over the three years of the study 357 cats representing 15 breeds, 45.3% female and 54.7% male, with a mean age of 3.8 years were evaluated. Of these 90.5% were blood type A, 5.6% type B, and 3.9% type AB. The majority of the cats (54.6%) were European DSH (92.3% were type A, 5.1% type B, and 2.6% type AB), and 21% were Maine Coon (MCO) cats (100% blood type A). The estimated frequencies of transfusion reactions following an unmatched transfusion between DSH (donors and recipients), MCO (donor and recipients), DSH donors and MCO recipients, and MCO donors and DSH recipients were 4.8%, 0%, 0%, and 5.1% for major reactions and 7.2%, 0%, 7.7%, and 0% for minor transfusions reactions, respectively. In a population of blood donors that includes DSH and MCO the risk of transfusion reaction is between 5% and 8% if typing is not performed on donor and recipient blood. Blood typing should therefore be performed before transfusion to remove the risk of transfusion reactions due to blood type incompatibilities.

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Section: Discussionmentioning

confidence: 99%

Signalment and Blood Types in Cats Being Evaluated as Blood Donors at Two Italian University Blood Banks

Spada

Miglio

Proverbio

et al. 2014

Veterinary Medicine International

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“…Inclusion criteria were primary cardiomyopathies, including HCM, dilated cardiomyopathy (DCM), unclassified cardiomyopathy (UCM), restrictive cardiomyopathy (RCM), and arrhythmogenic right ventricular cardiomyopathy. The echocardiographic diagnostic criteria for each phenotype were obtained from previous publications 39‐44 (Table S7). Congestive heart failure was diagnosed based on clinical history, presentation and evidence from thoracic radiography, ultrasonography or both, including pulmonary edema, pleural effusion, pericardial effusion, and ascites.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy

Liu

Köster

Fosgate

et al. 2020

Veterinary Internal Medicne

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Background: Currently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood.Objective: To identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly related to cardiovascular-renal axis disorder and systemic inflammatory response.Animals: Twenty-five cats in CHF caused by primary cardiomyopathy, 12 cats with preclinical cardiomyopathy, and 20 healthy controls.Methods: Case control and observational case series. The following serum biomarkers were compared among the 3 cat groups: a cardiorenal profile that included N-terminal pro-brain natriuretic peptide (NT-proBNP), symmetric dimethylarginine (SDMA), and creatinine and an inflammatory profile that included 7 acute-phase proteins (APPs).Survival analyses and longitudinal studies were performed in CHF cats.Results: All cardiorenal biomarkers were positively correlated and higher in CHF cats, and high NT-proBNP and SDMA were associated with poor clinical outcome. Cats with CHF had significantly higher leucine-rich alpha-2-glycoprotein 1, serum amyloid A, and International Small Animal Cardiac Health Council; IVSd, interventricular septum thickness at end diastole; LA, left atrial; LA/Ao, left atrial-to-aortic root ratio; LRG1, leucine-rich alpha-2-glycoprotein 1; LV FS, left ventricular fractional shortening; LVFWd, left ventricular free wall thickness at end diastole; NT-proBNP, N-terminal pro-brain natriuretic peptide; PCT, procalcitonin; PE, point estimate; RCM, restrictive cardiomyopathy; ROC, receiver operating characteristic; SAA, serum amyloid A; SDMA, symmetric dimethylarginine; SEC, spontaneous echocardiographic contrast; SPARCL, spatial proximity analyte reagent capture luminescence; UCM, unclassified cardiomyopathy.

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“…Estima-se que a prevalência da CMH em humanos seja de um a cada 500 indivíduos e, em pelo menos 60% dos casos, a doença é de origem familial (FERNANDEZ, 1998;GRAZIANO;ACQUATELLA, 2007;MARON et al, 2014). Em gatos, a prevalência de hipertrofia esquerda atribuída à CMH, observada em avaliações ecocardiográficas de felinos, encontra-se entre 14,5% e 34% (embora a hidratação, valores de tiroxina séricos e pressão arterial sistêmica não tenham sido mensurados em todos os animais) (PAIGE et al, 2009;WAGNER et al, 2010;CÔTÉ et al, 2011).…”

Section: Figura 1-unclassified

“…Coon e Persa, esta última tendo maior incidência dentre as quatro referidas (3-15% dos gatos com CMH são Persas), talvez por ser uma raça bastante comum (RUSH et al, 2002;MEURS et al, 2007). Côté et al (2011) incluem a esta lista as raças Siamesa, Abissínia e Birmanesa, apesar de apresentarem casos mais raramente. Há relatos de CMH geneticamente determinada no Sphynx, British Shorthair, Norwegian Forest, Turkish Van, American Shorthair e Scottish Fold (KITTLESON, 2009a;GRANSTRÖM et al, 2011;CHETBOUL et al, 2012;SILVERMAN;MEURS, 2012).…”

Section: Definição E Incidênciaunclassified

“…Há relatos de CMH geneticamente determinada no Sphynx, British Shorthair, Norwegian Forest, Turkish Van, American Shorthair e Scottish Fold (KITTLESON, 2009a;GRANSTRÖM et al, 2011;CHETBOUL et al, 2012;SILVERMAN;MEURS, 2012). No entanto, o gato doméstico de pelo curto (sem definição racial) é o felino mais acometido dentre os espécimes felinos CÔTÉ et al, 2011).…”

Section: Definição E Incidênciaunclassified

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<b>Avaliação genética de gatos da raça Persa:</b> mapeamento da mutação relacionada à cardiomiopatia hipertrófica de origem familial

Pellegrino¹

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À minha mãe científica, amiga e orientadora, professora Maria Helena Matiko Akao Larsson, por confiar e acreditar em mim desde aluna...por me motivar sempre quando foi preciso...por todo carinho, amor, confiança e amizade...pelos ensinamentos e conselhos pessoais e profissionais. Obrigada por me abrir portas e janelas...por me inserir no mundo da cardiologia que me faz tão realizada. Ao professor Bruno Cogliati, pela ajuda desde o início do projeto...por compartilhar experiências e por ajudar em toda avaliação genética...pela companhia desde as fases iniciais do nosso estudo...por acreditar na ciência e em bons resultados. À professora Alice Maria M.P.D. Libera...pela paz e alegria que transmite...por me ajudar, mesmo sem saber, nos momentos em que mais precisei de motivação...você é especial. Ao meu amigo e irmãozinho Fernando Caratti, por ser tão especial...por estar sempre perto...pela paz e alegria de uma amizade verdadeira...pela proteção, companheirismo...pela sensação de estar sempre bem e em sintonia...obrigada pela companhia, risadas e gordices! À Liz Marques, pela amizade, conselhos, risadas...por me acompanhar nas nossas inúmeras profissões...por estar sempre por perto e disposta a ajudar...pela nossa ligação...pelo quarteto! Aos meus pais, José Domingos Pellegrino e Inês Tezoni Pellegrino, pelo amor, carinho, preocupação, criação...pelos conceitos de certo e errado...pelo amor que recebi em minha infância. Obrigada, pai, pelo exemplo de honestidade e de coração puro que é...é muito bom saber que posso contar com você sempre. Ao meu irmão, Luís Fernando Pellegrino, pelas risadas e aventuras desde criança...por me ensinar que a vida deve ser levada mais leve...por estar sempre comigo nas nossas bagunças...por me fazer rir sempre! Às amigas Débora Santos Barone e Juliana Messias, pela companhia diária...por tornar o trabalho mais divertido...pela amizade, aventuras, risadas, conselhos, risos e choros...obrigada por estarem sempre por perto!

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Hypertrophic Cardiomyopathy

Cited by 16 publications

References 228 publications

Signalment and Blood Types in Cats Being Evaluated as Blood Donors at Two Italian University Blood Banks

Signalment and Blood Types in Cats Being Evaluated as Blood Donors at Two Italian University Blood Banks

Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy

<b>Avaliação genética de gatos da raça Persa:</b> mapeamento da mutação relacionada à cardiomiopatia hipertrófica de origem familial

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