Hypertrophic Osteoarthropathy

Pineda, Carlos; Martı́nez-Lavı́n, Manuel

doi:10.1016/j.rdc.2013.02.008

Cited by 50 publications

(36 citation statements)

References 65 publications

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“…Primary HOA, also known as pachydermoperiostosis, is a rare heredity condition with variable expressivity. Secondary HOA is most commonly associated with an intrathoracic malignancy, primarily pulmonary malignancies in 80%, including primary and metastatic lung cancer and intrathoracic lymphoma 2, 5. The arthralgia of HOA in the present patient developed during the clinical course of mesothelioma.…”

Section: Discussionmentioning

confidence: 60%

“…Pathogenesis of HOA is not fully understood. One hypothesis involves tumor production and the release of factors such as VEGF and GH into the circulation that promote features of HOA 2, 12, 13. However, the considerable reduction in tumor size and decreased serum level of GH with chemotherapy did not improve the severe arthralgia in the present patient.…”

Section: Discussionmentioning

confidence: 99%

“…Hypertrophic osteoarthropathy (HOA) is characterized by the coexistence of digital clubbing and periosteal proliferation of the tubular bones. Most cases of HOA associated with pulmonary lesions are lung cancers 2. Some patients complain of a burning sensation in the fingertips and may also suffer from excruciating bone pain 3, 4.…”

Section: Introductionmentioning

confidence: 99%

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A case of severe arthralgia with malignant mesothelioma‐associated hypertrophic osteoarthropathy

Yamakawa

Sekine

Kato

et al. 2016

Clinical Case Reports

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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A case of severe arthralgia with malignant mesothelioma‐associated hypertrophic osteoarthropathy

Yamakawa

Sekine

Kato

et al. 2016

Clinical Case Reports

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“…Homozygous and combined heterozygous mutation of this enzyme increases the level of PGE2 through impairment of its degradation process; on the other hand, mutation at SLCO2A1 results in impairment of PGE2 cellular uptake. Both of these mutations result in high PGE2 levels which stimulate various intracellular signaling pathways including VEGF which eventually leads to various clinical manifestations of PDP [1, 2]. …”

Section: Discussionmentioning

confidence: 99%

“…Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of the skin and bony structures at the distal extremities manifested by digital clubbing, periosteal bony reaction and joint effusion [1]. It is classified as either primary or secondary; the primary form is considered uncommon and accounts for about 3–5% of all cases.…”

Section: Introductionmentioning

confidence: 99%

Primary Idiopathic Osteoarthropathy: Could It Be Related to Alcoholism?

Alnimer

Subedi

Dawood

et al. 2017

Case Reports in Rheumatology

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Background. Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of the skin and bony structures at the distal extremities resulting in digital clubbing, periosteal bony reaction, and joint effusion. It can be primary (idiopathic) without any clear identifiable etiology as well as secondary to variety of systemic diseases most notably lung pathology. Case Presentation. We describe a rare case of primary idiopathic osteoarthropathy in a male patient who presented with severe pain and tenderness in his legs. His history was significant for long standing alcoholism. Physical examination showed severe fingers and toes clubbing. He reported similar changes in his mother. Clinical and radiological findings were remarkable for distal leg tenderness and diffuse periosteal bony reactions, respectively. Computerized tomography scan failed to show any pathology apart from fatty liver infiltration. In the absence of obesity or diabetes, this was consistent with alcoholic steatosis. He was started on nonsteroidal anti-inflammatory drug which dramatically improved his symptoms. Conclusion. Primary hypertrophic osteoarthropathy should be considered in a previously healthy person presenting with bony pain and finger clubbing especially after ruling out the common secondary causes. Moreover, alteration of prostaglandin metabolism secondary to alcoholic consumption might be a contributing factor.

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Genetic Disorders of Collagen, Elastin and Dermal Matrix

Burrows

2016

Rook's Textbook of Dermatology, Ninth Edition

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The inherited disorders of connective tissue are a heterogeneous group of conditions characterized by defects involving primarily one element of the connective tissue: collagen, elastic fibre or other extracellular matrix proteins. Multisystem involvement is common and can be fatal. There is variable skin involvement but recognition of characteristic skin findings may provide an early diagnosis and identify those at risk of internal complications. This chapter covers the inherited disorders of collagen and elastic fibres, infantile stiff skin and premature ageing syndromes, disorders of ectopic calcification and abnormal mineralization, as well as other syndromes related to abnormal connective tissue.

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Hypertrophic Osteoarthropathy

Cited by 50 publications

References 65 publications

A case of severe arthralgia with malignant mesothelioma‐associated hypertrophic osteoarthropathy

A case of severe arthralgia with malignant mesothelioma‐associated hypertrophic osteoarthropathy

Primary Idiopathic Osteoarthropathy: Could It Be Related to Alcoholism?

Genetic Disorders of Collagen, Elastin and Dermal Matrix

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